Analysis of bioactive compounds in lyophilized aqueous extracts of barley sprouts

Castro, Abigail García; Ortiz, Fabiola. A. Guzmán; Hernández, Guadalupe Herrera; Román-Gutiérrez, Alma D.

doi:10.1007/s11694-024-02569-9

Food Measure

2024

DOI: 10.1007/s11694-024-02569-9

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Analysis of bioactive compounds in lyophilized aqueous extracts of barley sprouts

Abigail García Castro,

Fabiola. A. Guzmán Ortiz,

Guadalupe Herrera Hernández

et al.

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2024

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Cited by 1 publication

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Antihypertensive Effect of Perla and Esmeralda Barley (Hordeum vulgare L.) Sprouts in an Induction Model with L-NAME In Vivo

García-Castro,

Román-Gutiérrez,

Guzmán-Ortiz

et al. 2024

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Background: Hypertension is one of the leading causes of premature death worldwide. Despite advances in conventional treatments, there remains a significant need for more effective and natural alternatives to control hypertension. In this context, sprouted barley extracts have emerged as a potential therapeutic option. This study presents the evaluation of the bioactive properties of extracts from two varieties of barley germinated for different periods (3, 5, and 7 days), focusing on their potential to regulate blood pressure mechanisms. Objectives/Methods: The main objective was to assess the effects of these extracts on blood pressure regulation in N(ω)-Nitro-L-Arginine Methyl Ester (L-NAME)-induced hypertensive rats. Renal (creatinine, urea, uric acid, and total protein) and endothelial (NOx levels) function, angiotensin-converting enzyme (ACE) I and II activity, and histopathological effects on heart and kidney tissues were evaluated. Results: In particular, Esmeralda barley extract demonstrated 83% inhibition of ACE activity in vitro. Furthermore, the combined administration of sprouted barley extract (SBE) and captopril significantly reduced blood pressure and ACE I and II activity by 22%, 81%, and 76%, respectively, after 3, 5, and 7 days of germination. The treatment also led to reductions in protein, creatinine, uric acid, and urea levels by 3%, 38%, 42%, and 48%, respectively, along with a 66% increase in plasma NO concentrations. Conclusions: This study highlights the bioactive properties of barley extracts with different germination times, emphasizing their potential health benefits as a more effective alternative to conventional antihypertensive therapies.

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Antihypertensive Effect of Perla and Esmeralda Barley (Hordeum vulgare L.) Sprouts in an Induction Model with L-NAME In Vivo

García-Castro,

Román-Gutiérrez,

Guzmán-Ortiz

et al. 2024

Metabolites

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show abstract

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Analysis of bioactive compounds in lyophilized aqueous extracts of barley sprouts

Cited by 1 publication

References 74 publications

Antihypertensive Effect of Perla and Esmeralda Barley (Hordeum vulgare L.) Sprouts in an Induction Model with L-NAME In Vivo

Antihypertensive Effect of Perla and Esmeralda Barley (Hordeum vulgare L.) Sprouts in an Induction Model with L-NAME In Vivo

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