Analysis of Biological Smooth Oscillators Inspired by the Relay Control Tuning Method

Zhang, Yan; Chen, Jian; Li, Guang

doi:10.3182/20140824-6-za-1003.02092

Cited by 1 publication

(1 citation statement)

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“…Goodwin developed the simplest model for limit cycle oscillations caused by negative feedback on gene expression [31][32][33] . Further studies suggest that the presence of positive feedback (PFB) in a circadian clock controls the regulation of the peak concentration of proteins 34 . Combination of a PFB with substrate depletion can also cause sustained oscillation 35 .…”

Section: Introductionmentioning

confidence: 99%

Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms

2023

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Temperature compensation and robustness to biological noise are two key characteristics of the circadian clock. These features allow the circadian pacemaker to maintain a steady oscillation in a wide range of environmental conditions. The presence of a time-delayed negative feedback loop in the regulatory network generates autonomous circadian oscillations in eukaryotic systems. In comparison, the circadian clock of cyanobacteria is controlled by a strong positive feedback loop. Positive feedback loops with substrate depletion can also generate oscillations, inspiring other circadian clock models. What makes a circadian oscillatory network robust to extrinsic noise is unclear. We investigated four basic circadian oscillators with negative, positive, and combinations of positive and negative feedback loops to explore network features necessary for circadian clock resilience. We discovered that the negative feedback loop system performs the best in compensating temperature changes. We also show that a positive feedback loop can reduce extrinsic noise in periods of circadian oscillators, while intrinsic noise is reduced by negative feedback loops.

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