To achieve zero CO2 emissions in the transport sector, hydrogen internal combustion engines (H2 ICE) appear to be one of the most promising solutions, particularly for heavy-duty applications. Achieving low NOx emissions requires ultra-lean combustion, which necessitates the use of high air-to-fuel ratios. To obtain this result, suitable boosting systems are required. This study aims to understand the behaviour of a turbocharger compressor. The performance of the compressor is strongly influenced by the unsteady flow generated by the motion of the engine’s intake valves. Achieving a more accurate prediction of engine performance in simulation models requires a deeper understanding of the pulsating flow performance. This understanding can be obtained through measurements conducted in specialized test facilities using appropriate measuring equipment. All the analyses reported in this paper take place at the Test Bench for Components of Propulsion System of the Department of Mechanical, Energy, Management and Transportation Engineering (DIME) of the University of Genoa. Following a short description of the instrumentations adopted, the actual experimental layout, the results obtained from the investigations on the compressor, operating under both steady and unsteady flow conditions, are outlined. The tested turbocharger compressor is coupled to the automotive engine intake circuit, where pulsating flow is generated by a motor-driven cylinder head. Different levels of turbocharger and camshaft rotational speeds are analyzed. For each operating condition, the unsteady performance of the compressor is assessed by measuring several instantaneous parameters, including inlet and outlet static pressure, mass flow rate, and turbocharger rotational speed. Furthermore, the effects of the intake circuit and its interaction with the compressor is deeply analyzed. In particular, the energy content associated with the pulses generated by the intake valves motion is taken into account, considering the hysteresis loops on the compressor map.