Analysis of Cardiovascular Risk Factors and Metabolic Syndrome in Korean Patients with Psoriasis

Kim, Gun‐Wook; Park, Hyun‐Je; Kim, Hoon-Soo; Kim, Suhan; Ko, Hyun‐Chang; Kim, Byung Soo; Kim, Moon‐Bum; Sim, Eun-Kyung

doi:10.5021/ad.2012.24.1.11

Cited by 52 publications

(61 citation statements)

References 20 publications

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“…Mebazaa et al .,[9] studied 164 psoriasis patients and 216 controls and showed a marginally higher prevalence of MS in psoriatic patients (35.5%) compared to controls (30.8%). Kim et al .,[10] also have studied 490 patients with psoriasis and 682 controls and found no statistical difference in MS between patients with psoriasis and controls ( P = 0.2).…”

Section: Discussionmentioning

confidence: 99%

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Metabolic syndrome in patients with psoriasis: A comparative study

Lakshmi

Nath

Udayashankar

2014

Indian Dermatol Online J

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Background:Psoriasis patients are at increased risk of developing the metabolic syndrome (MS). Proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6 that are increased in the psoriatic plaques are known to contribute to features of MS such as hypertension, dyslipidemia and insulin resistance.Aims:(1) To establish the frequency of MS in patients with psoriasis. (2) To study the risk factors associated with MS in psoriasis.Materials and Methods:A hospital based comparative study was conducted involving 40 adult patients with psoriasis and 40 age- and sex-matched controls. All participants were evaluated for components of MS.Results:Both groups included 31 males and 9 females. The mean age of the cases and controls were 49.95 years and 49.35 years, respectively. Psoriasis patients with MS had a statistically significant higher mean age (56.31 ± 11.36 years) compared with those without MS (46.89 ± 11.51 years). MS was present in 13 out of 40 (32.5%) patients with psoriasis and 12 out of 40 (30%) controls; this difference was not statistically significant. Higher age and female gender correlated with the presence of MS in psoriasis patients. The presence of MS in psoriasis patients was statistically independent of psoriasis area severity index score, body surface area involvement or psoriatic arthropathy.Conclusion:Our results suggest that there is no close correlation between psoriasis and MS in South Indian patients.

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Section: Discussionmentioning

confidence: 99%

“…Zindancı et al .,[7] and Mebazaa et al .,[9] also found that the prevalence of MS was independent of severity of psoriasis (PASI score). Kim et al .,[10] however, found that MS was associated with severe forms of psoriasis ( P = 0.048).…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome in patients with psoriasis: A comparative study

Lakshmi

Nath

Udayashankar

2014

Indian Dermatol Online J

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“…However, there have been other studies that found no significant difference in the prevalence of hypertension in psoriasis and control subjects [63,64]. In 388 psoriasis patients in Italy, there was a similar prevalence of hypertension among psoriatics and controls [34].…”

Section: Hypertensionmentioning

confidence: 68%

Comorbidities of psoriasis

Churton¹,

Doud

Korman

2013

Expert Review of Dermatology

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“…[9][10][11][12] Another study from Korea found the prevalence of metabolic syndrome in patients older than 53 years age. 13 Another hospital-based study found metabolic syndrome in psoriasis was more common after 40 years of age. 1 Gender wise male preponderance was observed in this study.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome in patients with chronic plaque psoriatic disease: a case-control study from western Uttar Pradesh, India

Jain

Singh

et al. 2018

Int J Res Med Sci

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Background: Various studies on psoriasis and metabolic syndrome have shown a large variation in their results. An increasing frequency is imposing a substantial burden on the overall health of psoriasis patients that needs to be appropriately foreseen and addressed. Aim of this study was to study various aspects of metabolic syndrome in patients with chronic plaque psoriatic disease in northern Indian region.Methods: A cohort of patients registering for treatment of chronic plaque psoriasis at Dermatology outpatients’ department formed the study population. Detailed history was captured. General physical examination was carried out. A thorough cutaneous examination was undertaken which captured details on type, distribution and arrangement of primary lesions and secondary changes in patients. After overnight fasting, venous blood samples were collected from the subjects and were analysed for serum glucose, triglyceride and HDL-cholesterol. Results: Metabolic syndrome in psoriasis was associated with higher age. Gender wise male preponderance was observed. Among the psoriasis cases, 64% had metabolic syndrome whereas among the control subjects 48% had the condition (p-value 0.158). The mean for serum triglyceride level for psoriasis patients (159.42 mg/dL) was higher than controls (144.25 mg/dL). Forty six percent of cases fulfilled elevated triglycerides ≥150 mg/dl as a criterion of metabolic syndrome, compared to 40% of controls. Conclusions: We observed a higher frequency of metabolic syndrome among psoriasis cases in a northern Indian population. An association of dyslipidemia with psoriasis was also noted. Routine screening of the condition to facilitate early diagnosis and treatment should be undertaken.

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Analysis of Cardiovascular Risk Factors and Metabolic Syndrome in Korean Patients with Psoriasis

Cited by 52 publications

References 20 publications

Metabolic syndrome in patients with psoriasis: A comparative study

Metabolic syndrome in patients with psoriasis: A comparative study

Comorbidities of psoriasis

Metabolic syndrome in patients with chronic plaque psoriatic disease: a case-control study from western Uttar Pradesh, India

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