Analysis of Cases of Central Nervous System Fungal Infections Reported in Japan between January 1979 and June 1989.

Mori, Takeshi; Ebe, Tsukasa

doi:10.2169/internalmedicine.31.174

Cited by 14 publications

(18 citation statements)

References 4 publications

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“…The diagnosis of Aspergillus CNS infection is considered to be very difficult. 7) Histological examination of inflammatory tissue should be performed if CSF examination fails to reveal the causative lesion.…”

Section: Discussionmentioning

confidence: 99%

“…In Japan, miconazole and fluconazole have been used since 1989 to treat Aspergillus infection. 7) CNS infections due to Aspergillus have a poor prognosis, because no drug has sufficiently effective activity against aspergillosis. 7) Fluconazole is absorbed well from the gastrointestinal tract and also penetrates the blood-brain barrier well, so is frequently used to treat fungal meningitis.…”

Section: Discussionmentioning

confidence: 99%

“…7) CNS infections due to Aspergillus have a poor prognosis, because no drug has sufficiently effective activity against aspergillosis. 7) Fluconazole is absorbed well from the gastrointestinal tract and also penetrates the blood-brain barrier well, so is frequently used to treat fungal meningitis. 6,7) No definitive method for the treatment of Aspergillus meningoencephalitis has yet been established, but fluconazole was effective in our case.…”

Section: Discussionmentioning

confidence: 99%

“…4,7) The routes of infection of the CNS are thought to be as follows: directly, most frequently through the paranasal sinus but also through the optic cavity and middle ear; hematogenous infection, usually originating in the lung but sometimes in the intestine; and trauma or operation. 1,4,5,9) The main organisms involved in fungal CNS infection are Cryptococcus neoformans, Candida species, and Aspergillus species.…”

Section: Introductionmentioning

confidence: 99%

“…1,4,5,9) The main organisms involved in fungal CNS infection are Cryptococcus neoformans, Candida species, and Aspergillus species. 7) Aspergillus infection of the CNS usually results from hematogenous spread from the lung or paranasal sinus because Aspergillus is a type of exogenous fungi. 2,4,7) We report a rare case of fungal meningitis caused by Aspergillus repeatedly occurring over a period of 15 years, and detected at the atrial side of the ventriculoatrial (VA) shunt at 15 years after onset.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Fungal Meningitic Hydrocephalus With Repeated Shunt Malfunction -Case Report-

Kagawa¹,

Okada

Moritake

2008

Neurol. Med. Chir.(Tokyo)

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A 33-year-old female presented with a rare case of fungal meningitis caused by Aspergillus detected for the first time at 15 years after onset. The meningitis repeatedly occurred over a period of 15 years. On admission, cerebrospinal fluid examination found cell count 1340/high-power field, protein 158 mg/dl, and sugar 8 mg/dl, indicating meningitis, although no bacterial or fungal species were detected. Cerebral computed tomography demonstrated hydrocephalus and cervical computed tomography demonstrated a mass lesion on the ventral side of the spinal cord from C4 to C6. Fungal meningitis was suspected and treated with amphotericin B. Her symptoms improved and she was eventually discharged. She was readmitted for recurrence of meningitis and hydrocephalus 2 months later. Amphotericin B was administered and a ventriculoperitoneal (VP) shunt was placed. Shunt malfunction recurred seven times. Aspergillus was detected for the first time from the atrium side of the ventriculoatrial shunt tube at 15 years after onset. Fluconazole was administered. She had narrowing of the cisterna magna, and underwent foramen magnum decompression. The VP shunt was finally reconstructed. Fluconazole administration was continued. Combination of foramen magnum decompression and long-term administration of fluconazole was effective in this case.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Fungal Meningitic Hydrocephalus With Repeated Shunt Malfunction -Case Report-

Kagawa¹,

Okada

Moritake

2008

Neurol. Med. Chir.(Tokyo)

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Infections and Inflammation in the Brain and Spinal Cord: A Dangerous Liaison

Dutta

Ghosh

Basu

2016

Inflammation: The Common Link in Brain Pathologies

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Candida Infection of Cerebrospinal Fluid Shunt Devices: Report of Two Cases and Review of the Literature

Montero

Romero

Vargas

et al. 2000

Acta Neurochirurgica

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Use of CSF shunt devices is a common practice in neurosurgery, and infection of the shunt is the most frequent complication. In spite of the fact that bacteria are the most widely implicated pathogens, reports of fungal infections, especially due to Candida sp., have increased in recent years. Their reported frequency ranges between 6% and 17%. Many factors have been implicated in the pathogenesis of Candida meningitis, such as broad spectrum antibiotics used in the treatment of a bacterial meningitis, steroids and indwelling bladder and intravenous catheters. The treatment of Candida meningitis still consists of systemic antifungal agents and removal of the shunt.

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Analysis of Cases of Central Nervous System Fungal Infections Reported in Japan between January 1979 and June 1989.

Cited by 14 publications

References 4 publications

Fungal Meningitic Hydrocephalus With Repeated Shunt Malfunction -Case Report-

Fungal Meningitic Hydrocephalus With Repeated Shunt Malfunction -Case Report-

Infections and Inflammation in the Brain and Spinal Cord: A Dangerous Liaison

Candida Infection of Cerebrospinal Fluid Shunt Devices: Report of Two Cases and Review of the Literature

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