In 2006 the Ministry of Health, Labor and Welfare (MHLW) has launched the 2006 Health care reform plan. One of the characteristics of this plan is to value the preventive activities. Most of these programs mainly focus to the disease specific symptoms and outcomes such as pain, weakness of muscle, and little attention is paid to the mental depression. In order to evaluate the effect of depressive situation on changes in Activity of Daily Living (ADL) level, we have organized and analyzed a two year's panel data (2004)(2005)) that contains about 1800 aged living in a city of western Japan. For evaluation of ADL level and depression status, Typology of Aged with Illustration (TAI) and Geriatric Depression Scale five item version (GDS5) were used, respectively. After evaluating the results of descriptive analyses, logistic regression analyses were conducted in order to analyze the factors associated with aggravation of ADL levels between 2004 and 2005. The results indicated that depressive status has significant influence on changes in ADL independency status, that is, the person with higher depression situation showed the higher possibility of worsening the ADL level. higher depression situation were related to the worsening of mobility (OR=0.749, 95%CI=0.655-0.857), mental status (OR=0.606, 95%CI=0.489-0.750), eating (OR=0.603, 95%CI=0.458-0.793), toileting (OR=0.564, 95%CI=0.456-0.698), and bathing (OR=0.647, 95%CI=0.551-0.760). The results of our study have suggested that the health promotion activities for the aged must pay enough attention for the depression problem in order to improve and to maintain their ADL independency.