Analysis of Cell Lineage in the Rat Cerebral Cortex<sup>a</sup>

Price, Jack; Williams, Brenda; Moore, R. Brantingham; Read, Joanne; Grove, Elizabeth A.

doi:10.1111/j.1749-6632.1991.tb15595.x

Cited by 4 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development of mature glia cells starts with the formation of multipotent neural precursors present within the ventricular and subventricular zones of the CNS. Their existence has been documented by retroviral labeling of neuroepithelial cells by the lacZ reporter gene or by Bromodeoxyuridine labeling of proliferating cells (4,5,6,7,8). These studies have revealed that the progenitor cells have a short cell cycle time.…”

Section: The Origin Of Gliomas; Perspectives From Developmental Biologymentioning

confidence: 99%

Mechanisms of tumor cell invasion and angiogenesis in the central nervous system

Visted

Enger²,

Lund‐Johansen³

et al. 2003

Front Biosci

View full text Add to dashboard Cite

Despite extensive progress in characterizing the genetic events involved in the development of gliomas, the cellular origin and the defined molecular mechanisms that lead to their occurrence are still unclear. It is known that tumours are of monoclonal origin. This is contrasted by the fact that gliomas frequently express features of different glial cell lineages. With the identification of pluripotent neural stem cells and the growth factors that control neural cell development, we are now making early inroads towards understanding glial cell migration as well as the neural cell plasticity within the adult central nervous system (CNS). Gliomas share several fetal antigens with immature brain cells. It is therefore tempting to speculate that the migration of neural precursor cells actually represents the normal counterpart of glioma cell migration. The migratory behavior of gliomas may be due to a predetermined interplay between normal brain tissue and the migrating cells, where the brain represents a permissive tissue for guiding cells with certain phenotypic traits to migrate along specific anatomical structures. Malignant progression is also accompanied by extensive angiogenesis which is especially prominent in glioblastoma multiforme (GBM). For cell proliferation to take place, several cell signaling cues mediated by specific growth factors are shared between the glioma cells and the endothelial cells while others are unique for endothelial cells. Therefore the endothelial cell compartment represents a promising target for novel therapeutic strategies including gene therapy and cell-based therapies.

show abstract

Section: The Origin Of Gliomas; Perspectives From Developmental Biologymentioning

confidence: 99%

Mechanisms of tumor cell invasion and angiogenesis in the central nervous system

Visted

Enger²,

Lund‐Johansen³

et al. 2003

Front Biosci

View full text Add to dashboard Cite

show abstract

Local Sonic Hedgehog Signaling Regulates Oligodendrocyte Precursor Appearance in Multiple Ventricular Zone Domains in the Chick Metencephalon

Davies

Miller

2001

Developmental Biology

View full text Add to dashboard Cite

In the chick metencephalon, oligodendrocyte precursors arise in distinct domains of the ventricular zone. During development, the earliest oligodendrocyte precursors appear in the metencephalic ventral ventricular zone adjacent to the midline, consistent with their location in the spinal cord. In contrast to spinal cord, however, distinct domains in the lateral and dorsal metencephalic ventricular zone subsequently generate oligodendrocyte precursors. All oligodendrogenic domains of the metencephalon appear in close apposition to regions that transiently express sonic hedgehog (Shh). Inhibition studies demonstrate a functional requirement for Shh signaling in the early appearance of metencephalic oligodendrocyte precursors, while in vitro studies suggest a dose-dependent increase in the number of oligodendrocyte precursors in response to Shh. In purified cultures of oligodendrocyte precursors, Shh promotes cell survival and proliferation, suggesting that Shh can act directly on these cells. These data suggest that Shh may be responsible for the localized appearance of oligodendrocyte precursors throughout the CNS, irrespective of the dorso-ventral neural axis.

show abstract

Recent Advances in Stem Cell Neurobiology

Ostenfeld

Svendsen

2003

Advances and Technical Standards in Neurosurgery

View full text Add to dashboard Cite

Analysis of Cell Lineage in the Rat Cerebral Cortex^a

Cited by 4 publications

References 18 publications

Mechanisms of tumor cell invasion and angiogenesis in the central nervous system

Mechanisms of tumor cell invasion and angiogenesis in the central nervous system

Local Sonic Hedgehog Signaling Regulates Oligodendrocyte Precursor Appearance in Multiple Ventricular Zone Domains in the Chick Metencephalon

Recent Advances in Stem Cell Neurobiology

Contact Info

Product

Resources

About

Analysis of Cell Lineage in the Rat Cerebral Cortexa

Cited by 4 publications

References 18 publications

Mechanisms of tumor cell invasion and angiogenesis in the central nervous system

Mechanisms of tumor cell invasion and angiogenesis in the central nervous system

Local Sonic Hedgehog Signaling Regulates Oligodendrocyte Precursor Appearance in Multiple Ventricular Zone Domains in the Chick Metencephalon

Recent Advances in Stem Cell Neurobiology

Contact Info

Product

Resources

About

Analysis of Cell Lineage in the Rat Cerebral Cortex^a