2020
DOI: 10.21203/rs.3.rs-121526/v1
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Analysis of cellular senescence in gingival tissues and gingival fibroblast cultures

Abstract: Senescence in periodontal tissues may be involved in the pathogenesis of periodontitis. In this study, we analyzed cellular senescence in gingival tissues of aged mice and in gingival fibroblast cultures and investigated the relationship of cellular senescence with the pathogenesis of periodontal disease. The proportions of senescence-associated β-galactosidase (SA-β-gal)-positive cells and the mRNA expression levels of p16 and p21 in gingival tissues and gingival fibroblasts from 20-month-old mice were signif… Show more

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“…Oxidative stress has been reported to induce gingival fibroblast senescence and the effect of alveolar bone cell senescence on periodontal disease 13) . Kiyoshima et al…”
Section: Discussionmentioning
confidence: 99%
“…Oxidative stress has been reported to induce gingival fibroblast senescence and the effect of alveolar bone cell senescence on periodontal disease 13) . Kiyoshima et al…”
Section: Discussionmentioning
confidence: 99%