Analysis of certain tranquilizers in biological fluids

Hefnawy, Mohamed M.

doi:10.1016/s0731-7085(01)00467-8

Cited by 18 publications

(7 citation statements)

References 219 publications

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“…The LLOD ranged from 0.1 to 1 ng/ml using sample volumes of 0.2-1 ml (Bagli et al, 1994;Foglia et al, 1995;Luo et al, 1997;Vanapalli et al, 2001). An excellent review of the determination of the PTZ group of compounds by HPLC can be referred to by Hefnawy (2002). Applications for the determination of amoxapine, loxapine, haloperidol, and associated metabolites by RP-HPLC can also be found in the literature (Cheung et al, 1991;Hue et al, 1998;Walter et al, 1998;Seno et al, 2000;Angelo and Petersen, 2001;Arinobu et al, 2002).…”

Section: Antipsychoticsmentioning

confidence: 99%

High‐Performance Liquid Chromatographic Analysis of Psychotropic and Endogenous Compounds

Odontiadis¹,

Rauw²

2007

Handbook of Neurochemistry and Molecular Neurobiology

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Section: Antipsychoticsmentioning

confidence: 99%

High‐Performance Liquid Chromatographic Analysis of Psychotropic and Endogenous Compounds

Odontiadis¹,

Rauw²

2007

Handbook of Neurochemistry and Molecular Neurobiology

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“…gas chromatography (GC) [12,13], high performance liquid chromatography (HPLC) [14,15], capillary electophoresis (CE) [16,17]. A method for the determination of some psychotropic drugs in different samples using TLC or HPTLC has been also described [18,19]. Some of the methods described determination of these drugs in plasma [11,20].…”

Section: Introductionmentioning

confidence: 99%

Determination of some psychotropic drugs in human plasma by HPTLC

Wróblewski

Petruczynik

Waksmundzka‐Hajnos

2014

Acta Chromatographica

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Summary. Psychotropic drugs: desipramine, olanzapine and mitrazapine were chromatographed on cyanopropyl-silica and Diol-silica thin layers using various nonaqueous and aqueous eluents.The best results were obtained with addition of ammonia to nonaqueous eluent on both adsorbents. On the basis of the optimization, systems for extraction from human plasma and quantitative determination of investigated drugs were selected.RP18 encaped SPE columns conditioned and pre-eluted with acetonitrile:water: ammonium buffer at pH 8.6 (5:5:2) and eluted with methanol:water (9:1) containing 2% acetic acid were used for sample preparation with high recoveries of all investigated drugs. Diol and CN plates with mixture of 15% methanol in diisopropyl ether + 1% ammonia were used for quantitative analysis by a calibration curve method.

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“…A review addressed the use of high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) as affinity separation methods to characterize drugs or potential drugs-biopolymer interactions [17]. Another one deals with the different methods of analysis of certain tranquilizers; phenothiazines, thioxanthenes, and benzodiazepine derivatives in biological fluids of pharmaceutical interest [18]. Only one elaborate report covered chromatographic methods, HPLC, LC-MS, GC, GC-MS published over the years 1992 to 1997 for the measurement of benzodiazepines in biological samples, which included samples preparation partially [19].…”

Section: Introductionmentioning

confidence: 99%