Analysis of Changes of Intestinal Flora in Elderly Patients with Alzheimer’s Disease and Liver Cancer and Its Correlation with Abnormal Gastrointestinal Motility

Zhang, Weiwei; Zhang, Xuelian; Zhang, Yanyan; Wu, Huanyu; Liu, Qiaoling; Zhou, Xinyu; Meng, Yunxia

doi:10.1155/2021/7517379

Cited by 7 publications

(9 citation statements)

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“…Actinobacteria Bifidobacteriaceae Coriobacteriaceae Decreased in IBS (247,248) Decreased in IBD (249,250) Decreased in UC and CD (251) Increased in IBS (248) Decreased in IBD (249) Increased in UC and CD (252) Increased in Parkinson's disease (253)(254)(255) Decreased in Alzheimer's disease (251) Decreased in autism spectrum disorder (256,257) Increased in bipolar disorder (258) Decreased in Parkinson's disease (259) Increased in bipolar disorder (258) Increases TPH1 and decreases SERT expression (260) Increases 5-HT in CNS (261) Increases mucosal 5-HT, and expression of SERT; 5-HTR 2 and 5-HTR 4 (237) Bifidobacterium are decreased in SERT -/mouse (262) Correlated with increased levels of serotonin (263) Microbial manipulation: prebiotic and probiotics in GI disorders (264)(265)(266) Probiotic supplementations in neurodegenerative disorders (267,268);…”

Section: -Ht Alterations Therapeutic Approachmentioning

confidence: 99%

“…Microbial manipulation: microbiota transplant in GI disorders (269)(270)(271)(272) Microbial manipulation: microbiota transplant in neurodegenerative disorders (273)(274)(275)(276) Natural products in neurodegenerative disorders (277,278) Natural products in GI disorders (279,280) Dietary fibers in GI disorders (281) Nanotechnology and nanotheranostic approach in neurodegenerative disorders (282)(283)(284) Oxidized phospholipidis (285,286) SCFAs in GI inflammatory disorders (287)(288)(289) CD36 in Alzheimer's disease (290) Firmicutes Clostridiaceae Decreased in IBS (291) Increased in IBD (292,293) Increased in CD (293) Increased in Parkinson's disease (284,294) Increased in autism spectrum disorder (256,257) Decreased in bipolar disorder (258) Increases mucosal 5-HT and EC cells and decreased SERT expression (295) Correlated with increased levels of serotonin (263) Increases SERT expression (296) Lachnospiraceae Decreased in IBS (291) Decreased in IBD (293,297) Decreased in UC and CD (298) Not modified in CD (252) Increased in UC (252) Decreased in Parkinson's disease (259,…”

Section: -Ht Alterations Therapeutic Approachmentioning

confidence: 99%

“…Reduced in IBD (293,297) Increased in IBS (248,302) Increased in UC (252) and in CD (293) Reduced in CD (252,298) Increased in Parkinson's disease (259) Increased in Alzheimer's disease (300) Decreased in autism spectrum disorder (301) Decreased in bipolar disorder (258) Increases 5-HT levels (232) Correlated with levels of serotonin (303) Veillonellaceae Increased in IBS (304,305) Increased in IBD (305,306) Increased in UC and CD (252) Decreased in autism spectrum disorder (256) Correlated with increased levels of serotonin (307) Lactobacillaceae Increased in IBS (248) Increased in IBD (297) Decreased in IBD (Lactobacillus) (250) Increased in CD and reduced in UC (252) Increased in Parkinson's disease (253,255,308) Decreased in Alzheimer's disease (251) Increased in Alzheimer's disease (300) Increased in autism spectrum disorder (257) Decreases TPH1, 5-THR 3 and 5-HTR 4 expression; and increases SERT expression…”

Section: Ruminococcaceaementioning

confidence: 99%

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Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis

et al. 2021

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Disruption of the microbiota–gut–brain axis results in a wide range of pathologies that are affected, from the brain to the intestine. Gut hormones released by enteroendocrine cells to the gastrointestinal (GI) tract are important signaling molecules within this axis. In the search for the language that allows microbiota to communicate with the gut and the brain, serotonin seems to be the most important mediator. In recent years, serotonin has emerged as a key neurotransmitter in the gut–brain axis because it largely contributes to both GI and brain physiology. In addition, intestinal microbiota are crucial in serotonin signaling, which gives more relevance to the role of the serotonin as an important mediator in microbiota–host interactions. Despite the numerous investigations focused on the gut–brain axis and the pathologies associated, little is known regarding how serotonin can mediate in the microbiota–gut–brain axis. In this review, we will mainly discuss serotonergic system modulation by microbiota as a pathway of communication between intestinal microbes and the body on the microbiota–gut–brain axis, and we explore novel therapeutic approaches for GI diseases and mental disorders.

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Section: -Ht Alterations Therapeutic Approachmentioning

confidence: 99%

Section: -Ht Alterations Therapeutic Approachmentioning

confidence: 99%

Section: Ruminococcaceaementioning

confidence: 99%

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Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis

et al. 2021

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“…To date, dysbiosis of intestinal microbiota in diabetes ( Xie et al., 2021 ), CVD ( Zhu et al., 2020 ), asthma ( Lu and Zou, 2020 ), and complex inflammatory diseases, including Alzheimer’s disease ( Shabbir et al., 2021 ; Zhang et al., 2021 ) and Parkinson’s disease ( Peng et al., 2021 ), has been discussed extensively. Non-communicable and metabolic diseases that impact bacterial translocation and dysbiosis in the blood are listed in Table 1 .…”

Section: Healthy Blood Bacteria Dysbiosis In Chronic Diseasesmentioning

confidence: 99%

Human circulating bacteria and dysbiosis in non-infectious diseases

Goraya

Mannan

et al. 2022

Front. Cell. Infect. Microbiol.

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Blood microorganisms were once thought to indicate infection. Blood in healthy people appears to be devoid of growing bacteria; nonetheless, intracellular dormant forms of bacteria have been reported previously. With breakthroughs in sequencing and bioinformatics, the presence of bacterial DNA in healthy human blood initiated the controversy of human blood microbiota (HBM). Recently, bacteria-specific DNA and culturable bacteria were found in healthy human blood. Researchers wanted to study the phenomena of a “healthy blood microbiota” by providing a thorough description of bacterially produced nucleic acids using many complementing molecular and traditional microbiological approaches. Because blood is a relatively limited and particular environment, culturability and plate count issues can be overcome using enhanced cultured procedures. However, more evidence is required to confirm that healthy human blood contains normal microbiota. Cavities, mouth and intestinal microbiota, trauma, surgery, and animal/insect bites can introduce bacteria into human blood. All these factors strengthen the concept of transient blood bacteria too. The presence of blood bacteria may be caused by temporary immunological clearance and absorption by dendritic or M cells. This review provides an extensive and comprehensive analysis that suggests that healthy blood bacteria may not be typical microbiota but transient circulatory microorganisms. In this study, we look at how contaminants (Escherichia, Shigella, Pseudomonads, etc.) from the skin, laboratory environments, and reagents can affect the interpretation of blood-derived microbial information and the relationship between the circulating bacteria and non-communicable diseases. Circulating transient bacteria may play a role in the pathogenesis of non-infectious diseases such as diabetes and CVD. Contamination-free hematological studies can aid in understanding the disease mechanisms, therapy, and biomarkers.

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“…Motilin (MTL) is a polypeptide composed of 22 amino acids secreted by intestinal chromaffin cells. It acts on gastrointestinal smooth muscle and intestinal nervous system, playing a role in gastrointestinal motility ( Kitazawa and Kaiya, 2021 ; Tack et al, 2021 ), and is involved in various gastrointestinal diseases ( Van den Houte et al, 2020 ; Wang T. et al, 2020 ; Ko et al, 2021 ; Zhang et al, 2021 ). MTL binds to MTL receptors (MTLRs) that are located primarily in the enteric nerves, smooth muscle, and gastric vagal nerve terminals of the gastrointestinal (GI) tract ( Kitazawa and Kaiya, 2021 ; Li et al, 2021 ; Miedzybrodzka et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Motilin and its receptor are expressed in the dorsal horn in a rat model of acute incisional pain: Intrathecal motilin injection alleviates pain behaviors

Zhao¹,

Hu²,

Wang³

et al. 2023

Front. Neurosci.

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AimsTo observe the effects of intrathecal administration of motilin on pain behavior and expression of motilin (MTL)/motilin receptor (MTLR) in the spinal cord of a rat model of acute incisional pain.MethodsAn incisional pain model was established in rats using a unilateral plantar incision. The rats were also injected intrathecally with 1, 5, or 25 μg of motilin. The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were determined. MTL/MTLR expression in the spinal cord was detected by western blotting and immunofluorescence. The expression of MTL in the spinal cord, stomach, duodenum, and plasma was determined by enzyme-linked immunosorbent assay (ELISA).ResultsMotilin/motilin receptor were detected in the spinal cord. Spinal cord MTL/MTLR expression peaks at 2 h after modeling (P < 0.05) and start to decrease at 24 h (P < 0.05) to almost reach baseline levels at 72 h. The changes in gastric, duodenal, plasma, and spinal cord motilin levels correlated with MWT and TWL (all R2 > 0.82). The intrathecal injection of 1, 5, or 25 μg of motilin could increase the pain threshold of rats with incisional pain within 72 h in a dose-dependent manner.ConclusionThis study showed for the first time that MTL/MTLR are expressed in rats’ spinal dorsal horn. Acute pain increased MTL/MTLR expression in the spinal dorsal horn. Also, for the first time, this study showed that motilin intrathecal injection alleviates pain in rat models of acute incisional pain. These results suggest that MTL/MTLR could be a novel target for the management of acute pain.

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Analysis of Changes of Intestinal Flora in Elderly Patients with Alzheimer’s Disease and Liver Cancer and Its Correlation with Abnormal Gastrointestinal Motility

Cited by 7 publications

References 5 publications

Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis

Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis

Human circulating bacteria and dysbiosis in non-infectious diseases

Motilin and its receptor are expressed in the dorsal horn in a rat model of acute incisional pain: Intrathecal motilin injection alleviates pain behaviors

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