2024
DOI: 10.21203/rs.3.rs-4407880/v1
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Analysis of Clinical Features and Treatment Strategies in Advanced Lung Adenocarcinoma Patients With Acquired ALK Fusion After Resistance of EGFR-TKIs

Yuan Yang,
Baohua Lu,
Liang Shi
et al.

Abstract: Background The mechanism of secondary drug resistance in advanced Non Small Cell Lung Cancer(NSCLC) patients with Epidermal Growth Factor Receptor (EGFR) gene sensitive mutation after EGFR-Tyrosine Kinase Inhibitors (TKIs) is complex. Acquired Anaplastic Lymphoma Kinase (ALK) fusion mutation is a rare type, and there are few reports on the clinical characteristics and treatment options for this group of patients. Methods Cases of 820 locally advanced or metastatic EGFR-sensitive mutations NSCLC patients whos… Show more

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