Analysis of Clinical Symptoms and Brain MRI of Heat Stroke: 2 Case Reports and a Literature Review

Shimada, Tomoyo; Miyamoto, Nobukazu; Shimada, Yoshiaki; Watanabe, Masayuki; Shimura, Hideki; Ueno, Yoshio; Yamashiro, Kazuo; Urabe, Takao

doi:10.1016/j.jstrokecerebrovasdis.2019.104511

Cited by 17 publications

(9 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of the injurious nature of EHS, studies investigating EHS in humans are retrospective or clinical. Retrospective studies examine the effects of heat stroke irrespective of population differences and only characterize the adverse events regardless of whether it is classical or EHS (Deshwal et al., 2017; Ninan et al., 2020; Shimada et al., 2020). Clinical studies address how to identify and improve cooling treatments for heat stroke to reduce lethality (Knapik & Epstein, 2019; Kumar & Singh, 2021; Sankar et al., 2020).…”

Section: Mouse Models Provide Insight Into Mechanisms Impossible To S...mentioning

confidence: 99%

“…Transgender individuals adopt gender expression consistent with their gender identity (Klein et al, 2018;Pereira-Garcia et al, 2021), which can include gender affirming hormone therapy (GAHT) with or without surgery. Additionally, an increasing number of younger people prefer non-binary rather than binary terms (Smith et al, 2014;Jones et al, 2021;Pereira-Garcia et al, 2021). When GAHT or surgery is a part of transition, these changes are usually associated with altered hormonal milieu, and may have important effects on thermoregulation as they do on other physiological systems (Colizzi et al, 2015;Elbers et al, 2003;Emi et al, 2008;Irwig, 2018;Maraka et al, 2017;Millington et al, 2020;Wierckx et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Are there sex differences in risk for exertional heat stroke? A translational approach

Giersch

Garcia

Stachenfeld

et al. 2022

Experimental Physiology

View full text Add to dashboard Cite

New Findings What is the topic of this review?Whether there are sex differences in exertional heat stroke. What advances does it highlight?This review utilizes a translational model between animal and human research to explore possible physical and physiological differences with respect to risk and treatment of exertional heat stroke. Abstract Exertional heat stroke (EHS) is a potentially fatal condition brought about by a combination of physical activity and heat stress and resulting in central nervous system dysfunction and organ damage. EHS impacts several hundred individuals each year ranging from military personnel, athletes, to occupational workers. Understanding the pathophysiology and risk factors can aid in reducing EHS across the globe. While we know there are differences between sexes in mechanisms of thermoregulation, there is currently not a clear understanding of if or how those differences impact EHS risk. The purpose of this review is to assess the current status of the literature surrounding EHS from risk factors to treatment using both animal and human models. We use a translational approach, considering both animal and human research to elucidate the possible influence of female sex hormones on temperature regulation and performance in the heat and highlight the specific areas with limited research. While more work is necessary to comprehensively understand these differences, the current research presented provides a good framework for future investigations.

show abstract

Section: Mouse Models Provide Insight Into Mechanisms Impossible To S...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Are there sex differences in risk for exertional heat stroke? A translational approach

Giersch

Garcia

Stachenfeld

et al. 2022

Experimental Physiology

View full text Add to dashboard Cite

show abstract

“…The central nervous system is highly sensitive to hyperthermia, leading to neurological complications due to the involvement of the cerebellum, basal ganglia, and peripheral nerves. There are various manifestations of nervous system injuries after HS, including cerebellar injury, subarachnoid hemorrhage, peripheral nerve injury, and so on (2). However, what is the relationship of HS and Guillain-Barré syndrome (GBS)?…”

Section: Introductionmentioning

confidence: 99%

Analysis of Clinical Symptoms of Guillain–Barré Syndrome Induced by Heat Stroke: Three Case Reports and Literature Review

Wang²,

Guo³

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

BackgroundHeat stroke is a potentially fatal condition that is caused by elevated core temperature. Guillain–Barré syndrome (GBS) induced by heat stroke is extremely rare and has only been reported in few case reports. The purpose of this case study was to evaluate the clinical symptoms, neuroelectrophysiological and imageological features of GBS after heat stroke.MethodsWe reviewed our hospital records and previously published reports to find the cases of GBS after heat stroke. The clinical, imageological, and electrophysiological profiles, treatment and prognosis were presented and analyzed.ResultsWe retrieved three cases of GBS induced by heat stroke from our hospital, which presented as lesions on multiple cranial and peripheral nerves and albuminocytologic dissociation in the cerebrospinal fluid. All of these patients had disorders of consciousness at the early stage of heat stroke and a “pseudo-recovery period” after they recovered from coma after heat stroke. After immunoglobulin administration and immunoregulation therapy, these patients' neurological deficiencies were relieved significantly. But there are still disabilities and almost totally reliant on others.ConclusionsThe number of the cases of GBS induced by HS reported in this study has been the most in the recent 5 years. Clinicians should pay attention to patients with heat stroke with sustained coma and the sudden quadriplegia. Early, exact and timely diagnosis and treatment of GBS need to be performed, to accelerate recovery and improve prognosis.

show abstract

“…Heatstroke encephalopathy presents with abnormal head magnetic resonance imaging (MRI) signals [ 1 , 2 ]. Ischemia-like lesions on MRI are caused by low blood flow and abnormal coagulation, whereas posterior reversible encephalopathy syndrome (PRES)-like lesions result from direct heat and angiogenic edema due to hypercytokinemia [ 3 ]. However, the use of this imaging method and its therapeutic consequences remain controversial.…”

Section: Introductionmentioning

confidence: 99%

A Case of Heatstroke Encephalopathy With Abnormal Signals on Brain Magnetic Resonance Imaging

Hiramatsu¹,

Hisamura²,

Murase³

et al. 2021

Cureus

View full text Add to dashboard Cite

Herein, we present a case of heatstroke encephalopathy with abnormal brain magnetic resonance imaging (MRI) signals. A 19-year-old man lost consciousness while working outdoors when the temperature was 35°C. His Glasgow Coma Scale score at presentation was E1V1M1, and his body temperature was 39°C. Chest computed tomography revealed bilateral infiltrates, and tests for urinary pneumococcal antigens were positive. He was diagnosed with heatstroke preceded by pneumococcal pneumonia. He was subsequently treated with antibiotics, and body surface cooling was performed. A diffusion-weighted brain MRI performed on day eight revealed abnormal bilateral hyperintensities from the cortex at the frontal lobe apex of the subcortex. Moreover, he had reduced spontaneity, dysarthria, nystagmus, tremor, and ataxia of both the upper limbs. He was diagnosed with heatstroke encephalopathy. On day 28 since admission, the abnormal MRI signals disappeared. Subsequently, the patient’s spontaneity improved, but his other neurological dysfunctions persisted. This case study demonstrates that MRI may not be a sensitive indicator of the prognosis of heatstroke encephalopathy.

show abstract

Analysis of Clinical Symptoms and Brain MRI of Heat Stroke: 2 Case Reports and a Literature Review

Cited by 17 publications

References 32 publications

Are there sex differences in risk for exertional heat stroke? A translational approach

Are there sex differences in risk for exertional heat stroke? A translational approach

Analysis of Clinical Symptoms of Guillain–Barré Syndrome Induced by Heat Stroke: Three Case Reports and Literature Review

A Case of Heatstroke Encephalopathy With Abnormal Signals on Brain Magnetic Resonance Imaging

Contact Info

Product

Resources

About