Analysis of Clinicopathologic Characteristics and Prognosis of Gastric Cancer in Young and Older Patients

Abstract

With regard to resectability, 78 % of the tumors were resected in the group of younger patients, the surgery more frequently achieved was total gastrectomy with anastomosis in Y of Roux. In the elder group, about 62 % of the tumors were resected and BII gastrectomy was the most frequent surgery. The diffuse adenocarcinoma was the most frequent histological type in younger patients, whereas in older patients was intestinal adenocarcinoma. With regard to the stage in the first group there was a predominance of stages: IA and IV (26.1 %) in the second: IV (25.8 %). The survival for stage III e IV was significantly worst in YGC compared with OGC.

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

“…However, there has been some concern about a trend toward steadily increasing GC in young patients over the past few decades and studies were conducted to define the demographic, clinicopathologic and prognostic factors of GC in young patients [10][11][12]. The incidence of GC in patients aged 40 years or younger ranges from 4.6 to 6.2 % [12][13][14].…”

“…Features reported more frequently in young patients compared with old patients included female predominance, a significantly higher proportions of Lauren's diffuse-type cancers amongst all tumor types, and poorly differentiated histologic tumor types [15][16][17]. Although some studies have analyzed GC characteristics in young patients [10][11][12], there are currently no reported studies that evaluated GC in extremely young adult patients aged 30 years or younger. Thus, little is known regarding predictors of GC survival for this group or for the subgroups who underwent resection.…”

Clinical Outcomes of Endoscopic Submucosal Dissection in Patients under 40 Years Old with Early Gastric Cancer

“…[6][7][8][9][10] Because most previous studies included young patients with early gastric cancer (EGC) and advanced gastric cancer, the enrolled young patients showed more advanced-stage and metastatic disease at the time of diagnosis. Owing to awareness about rapid progression in young patients, there are concerns about endoscopic treatment in young patients with EGC that met the expanded indication of endoscopic submucosal dissection (ESD).…”

Modern concepts of factors for gastric cancer progression

“…Значение имеет не только наличие метастазов, но и количество пораженных лимфатических узлов, их локализация [8][9][10][11]. Риск лимфогенного метастазирования повышается с увеличением размера и глубины инвазии опухоли [8, 9, 12, 13] при диффузном типе рака желудка, низкодифферен-цированных и недифференцированных опухолях [14,15], при на-личии лимфатической и венозной инвазии [8, 9, 13,16].Ухудшение отдаленных результатов лечения отмечено при локализации опухоли в проксимальной трети желудка [7,17,18] и у лиц молодого возраста [19,20]. Ухудшение выживаемости у мо-лодых пациентов связывают с преобладанием у них диффузных и недифференцированных опухолей (68% против 25% у пожилых), более частой проксимальной локализацией опухоли и более рас-пространенными стадиями заболевания.…”

“…Ухудшение отдаленных результатов лечения отмечено при локализации опухоли в проксимальной трети желудка [7,17,18] и у лиц молодого возраста [19,20]. Ухудшение выживаемости у мо-лодых пациентов связывают с преобладанием у них диффузных и недифференцированных опухолей (68% против 25% у пожилых), более частой проксимальной локализацией опухоли и более рас-пространенными стадиями заболевания.…”