Analysis of colorectal cancer survival rate at a single institution

Dharmaji, Aditya Bernard; Mappincara,; Kusuma, Muhammad Ihwan; Sampetoding, Samuel; Warsinggih,; Labeda, Ibrahim; Uwuratuw, Julianus Aboyaman; Syarifuddin, Erwin; Hendarto, Joko

doi:10.1016/j.mcpsp.2021.100232

Cited by 7 publications

(8 citation statements)

References 26 publications

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“…Colorectal cancer (CRC) is the third most prevalent cancer and the fourth most common cause of death worldwide. The incidence and mortality rates of CRC vary geographically [ [1] , [2] , [3] , [4] ]. The global burden of CRC is predicted to increase by 60%, corresponding to more than 2.2 million new cases and 1.1 million deaths by 2030 [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…The global burden of CRC is predicted to increase by 60%, corresponding to more than 2.2 million new cases and 1.1 million deaths by 2030 [ 5 ]. CRC is one of the most common cancers in Indonesia, and its incidence is slowly increasing [ 3 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…According to the International Agency for Research on Cancer (IARC) Global Cancer Observatory's GLOBOCAN 2018 database, the incidence of CRC in Indonesia was 30,017 out of 348,809 cancer cases, and it had the fifth-highest mortality rate (7.7%) among all cancers [ 3 , 7 ]. The differences in survival rates observed in clinical trials may have been due to variations in patients' characteristics and prognostic factors [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Colorectal cancer survival rates in Makassar, Eastern Indonesia: A retrospective Cohort Study

Labeda

Lusikooy

Mappincara

et al. 2022

Annals of Medicine &Amp; Surgery

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Background The 5-year overall survival (OS) rate for colorectal cancer (CRC) has been reported as 39%, and the 5-year recurrence-free survival (RFS) rate has been reported as 14%. Various prognostic factors have been associated with differences in survival rates among CRC patients. This study investigated the difference between several prognostic factors and the OS and RFS rates of CRC patients at the Dr. Wahidin Sudirohusodo General Hospital Makassar in Indonesia. Materials and methods The study group comprised all CRC patients treated at the Division of Digestive Surgery from 2014 to 2016. Prognostic factor data were collected from medical records for 293 patients. The OS and RFS rates were analyzed using the bivariate Kaplan–Meier method and log-rank tests. Results Log-rank analysis of the association of age, histopathology, stage, definitive surgery, chemotherapy, and radiotherapy with the OS rate showed p -values of 0.031, 0.009, 0.014, 0.000, 0.343, and 0.381, respectively. Log-rank analysis of the association of these prognostic factors with the RFS rate showed p -values of 0.282, 0.006, 0.008, 0.020, 0.002, and 0.000, respectively. Conclusion There were significant differences in the OS rate according to age, histopathology, stage, and history of definitive surgery. Histopathology, stage, history of definitive surgery, and chemotherapy and radiotherapy were significantly associated with differences in the RFS rate.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Colorectal cancer survival rates in Makassar, Eastern Indonesia: A retrospective Cohort Study

Labeda

Lusikooy

Mappincara

et al. 2022

Annals of Medicine &Amp; Surgery

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“…10 This study revealed that colorectal cancer patients' survival rates dwindled from the first year (87.9%) to the fifth year (45.4%). 11,19 This disparity could probably be linked to the difference in the advancement of screening, diagnostic and treatment facilities. 15 The low probability of survival rate could be linked to the late diagnosis and delayed treatment in the study setting due to inadequate cancer treatment centers in resource-limited settings.…”

Section: Discussionmentioning

confidence: 99%

“… 24 Lung and liver were the most prevalent sites of metastasis, collaborating with similar studies. 19 , 25 , 26 These patients have a much lower chance of achieving long‐term remission than those with localized cancer since metastatic tumors are mostly unresponsive to the existing therapies.…”

Section: Discussionmentioning

confidence: 99%

Survival outcomes among colorectal cancer patients at Kenyatta National Hospital: A retrospective cohort study

et al. 2022

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Background: Colorectal cancer is a growing burden in Africa. However, survival for patients with colorectal cancer remains low in sub-Saharan African countries, with the poorest survival, particularly at a late stage at diagnosis. Despite this, there is a paucity of sufficient data about the survival outcomes of colorectal cancer patients in Kenya.Aims: This study aimed to determine the survival outcomes among colorectal cancer patients at Kenyatta National Hospital. Methods and Results: A retrospective cohort study was employed among 232 eligible medical records of colorectal cancer patients. Simple random sampling was used to select the medical records of the patients. The included medical records of the study participants were followed up retrospectively from the date of primary cancer diagnosis until the last visit to the hospital. All relevant data, such as sociodemographics, clinical characteristics, and outcome-measuring parameters, were recorded in the predesigned data abstraction tool by reviewing the documented clinical records of the patients. The data were entered and analyzed using International Business Machines (IBM) Statistical Package for the Social Sciences (SPSS) version 26 software.Mean, median, standard deviation, frequency tables, and figures were used to present the data. Kaplan Meier analyses were employed to determine survival outcomes.The mean age of the study participants was 54.1 ± 13.3 years, and the majority were males (126, 54.3%). Almost a third (34.1%) of patients had evidence of disease progression despite treatment in the follow-up period, with 7.8% showing no response to therapy and 23.6% experiencing new distant metastasis. The survival rate dwindled from the first year (87.9%) to the fifth year (45.4%), and the mortality rate was 22.8% Conclusion: There was a high mortality rate, disease progression, and distant metastasis in the last follow-up period suggesting the need to strengthen the healthcare system by ensuring access to prevention, early diagnosis, and optimal treatment of colorectal cancer.

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TGF-β and SMAD2/4 Expression in Nonmetastatic and Metastatic Colorectal Cancer Patients

Mardiah,

Susanto,

Lestari

2024

BIO Web Conf.

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Colorectal cancer (CRC) is the third most common and second cancer with the highest mortality rate in the world. The leading cause of death in colorectal cancer patients is cancer that has metastasized, with the most common site of metastasis being the liver. One of the signaling that regulates malignancy of cancer cells is TGF-β/Smad. Through activation of the Smad2/3/4, TGF-β regulates the EMT Transcription factors to activate Epithelial Mesenchymal Transition (EMT) program. Tumor cells that have undergone EMT have migratory, invasive, and metastatic phenotypes. This study aims to know the differences mRNA expression of TGF-β, Smad2, and Smad4 in metastatic colorectal cancer and non-metastatic groups using real time PCR method. The results showed TGF-β and Smad2 expression in metastatic CRC was higher in the metastatic group than in the non-metastatic group. In contrast, Smad4 expression was found to be higher in the nonmetastatic group. The results suggest that TGF-β/Smad signaling pathway has a role in promoting metastasis and severity in CRC patients.

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Analysis of colorectal cancer survival rate at a single institution

Cited by 7 publications

References 26 publications

Colorectal cancer survival rates in Makassar, Eastern Indonesia: A retrospective Cohort Study

Colorectal cancer survival rates in Makassar, Eastern Indonesia: A retrospective Cohort Study

Survival outcomes among colorectal cancer patients at Kenyatta National Hospital: A retrospective cohort study

TGF-β and SMAD2/4 Expression in Nonmetastatic and Metastatic Colorectal Cancer Patients

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