Analysis of common causes of liver damage among children 12 years and younger in Weifang

Meng, Qingyu; Li, Na; Yuan, Lianmei; Gao, Xiaona

doi:10.1177/03000605211006661

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…The symptoms can vary greatly, with a range of presentations including asymptomatic elevation in aminotransferases, cholestasis, acute liver failure, hepatic fibrosis, and cirrhosis ( 18 ). Consistent with prior research conducted in another region of China ( 19 ), infection remained the most common entity encountered, especially EBV and CMV infections in this study. CMV hepatitis is predominantly seen in young infants, whereas EBV hepatitis is predominantly seen in children over 1 year of age.…”

Section: Discussionsupporting

confidence: 92%

The epidemiological characteristics of liver disease in hospitalized children: a 10-year single-center retrospective study

Chen,

Huang,

Huang

et al. 2024

Front. Pediatr.

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BackgroundThis investigation aimed to examine the epidemiological characteristics of children with liver disease hospitalized for the first time between June 2012 and May 2022 in a tertiary hospital.MethodsThe study retrospectively recruited children aged between 29 days and 18 years who had been hospitalized for liver disease. Clinical characteristics were categorized by age and etiology, and time trends were assessed using linear regression analysis.ResultsA total of 4,313 children were recruited, with a median age of 0.7 (0.2–4.5) years, and 54.5% of the cases were in the 0–1 years age group. Infection was the primary cause of liver disease (30.0%), followed by undiagnosed cases (25.8%), biliary obstructive disease (15.9%), inherited metabolic liver disease (13.9%), and non-alcoholic fatty liver disease (NAFLD) (3.2%). Genetic diagnoses were established in 43.9% (478/1,088) of patients. The percentage of NAFLD demonstrated an upward trend from 1.2% in 2012 to 12.6% in 2022 (p = 0.006). In contrast, the percentage of cytomegalovirus hepatitis decreased from 13.3% in 2012 to 3.4% in 2022 (p = 0.002).ConclusionsLiver disease in infancy makes up the largest group in pediatric liver disease. Infection remains the leading cause of pediatric liver disease. Hospital admissions for NAFLD in children have increased rapidly over the past decade, while cytomegalovirus hepatitis has declined markedly.

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Section: Discussionsupporting

confidence: 92%

The epidemiological characteristics of liver disease in hospitalized children: a 10-year single-center retrospective study

Chen,

Huang,

Huang

et al. 2024

Front. Pediatr.

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“…Biliary atresia is the commonest primary aetiology requiring LT in children across the world. Among the rest, autoimmune liver disease, metabolic and genetic liver diseases such as Wilson disease, progressive familial intrahepatic cholestasis and liver malignancies predominate [1,2]. Paediatric liver transplant [PLT] is demanding due to the inherent nature of smaller body proportions.…”

Section: Introductionmentioning

confidence: 99%

First paediatric live donor liver transplant in Sri Lanka with 1 year outcome : challenges for the future

et al. 2021

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IntroductionLiver transplantation in the paediatric age group is demanding due to smaller body proportions and physiology. This paper describes the first successful paediatric liver transplant in Sri Lanka along with its one-year outcome. Describing the challenges faced during the process, we highlight the factors that need to be considered for a sustainable programme in the future. MethodologyA 9-year-old girl who had progressive familial intra hepatic cholestasis type 3 was referred to us with features of end stage liver disease. She was identified as a suitable candidate for liver transplantation. Her 38-year-old mother was selected as the donor, who was evaluated for suitability of a left lateral segment donation. ResultsThe first paediatric liver transplantation was performed in July 2020. The child's mother donated the left lateral segment weighing 325g. During the postoperative period the child developed outflow tract obstruction at the hepatic venous anastomosis. This was managed with a percutaneously placed stent. Six months after transplant, she developed an acute rejection that required steroids. Treatment of rejection was complicated with multiple liver abscesses caused by Aspergillus. The infection was treated with systemic antifungals and drainage. At one-year post transplant, the recipient had recovered from the trauma of surgery and had normal liver biochemistry, a patent hepatic venous stented anastomosis and complete resolution of the abscesses. We faced dual challenges in dealing with a live liver transplant donor and a young child who was the recipient. Our success, on this occasion, was underscored by the multidisciplinary contribution from specialists scattered across the island combined with state-public partnership.

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“…However, the safety and efficacy of omadacycline in pediatric patients aged 8-18 years remain unclear (Burgos and Rodvold, 2019). M. pneumoniae infection and antiinfective drugs have a high tendency to cause liver and kidney impairment in pediatric patients, as the liver and kidney functions of children are not yet fully developed (Meng et al, 2021). Pharmacokinetic studies have shown that omadacycline is widely distributed in most tissues throughout the body after administration, with high plasma concentrations achieved in lung tissue.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Omadacycline in the treatment of macrolide-unresponsive Mycoplasma pneumoniae pneumonia in an adolescent patient

Xu,

Fang

2023

Front. Cell. Infect. Microbiol.

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Omadacycline is a novel tetracycline antibiotic that exhibits good in vitro antibacterial activity against atypical pathogens such as Mycoplasma pneumoniae. It is approved for the treatment of adults with community-acquired bacterial pneumonia. However, the safety and efficacy of omadacycline in pediatric patients under 18 years of age have not yet been established. In the present paper, we report a case of pediatric community-acquired pneumonia in which initial empirical anti-infective therapy had failed. The patient received empirical anti-infective therapy with azithromycin and other antimicrobial agents upon admission but showed a poor clinical response and developed secondary tinnitus and liver dysfunction. After the confirmation of M. pneumoniae infection through metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid, an antibiotic switch to omadacycline was made. Thereafter, the patient’s condition improved, and no adverse reactions were observed. These findings demonstrate that mNGS enables the identification of infection-causing pathogens in patients with unresponsive pneumonia. Omadacycline can be considered as an alternative option for anti-infective therapy in pediatric M. pneumoniae pneumonia, especially when the presence of bacterial resistance, adverse drug reactions, or organ failure are taken into consideration.

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Analysis of common causes of liver damage among children 12 years and younger in Weifang

Cited by 4 publications

References 16 publications

The epidemiological characteristics of liver disease in hospitalized children: a 10-year single-center retrospective study

The epidemiological characteristics of liver disease in hospitalized children: a 10-year single-center retrospective study

First paediatric live donor liver transplant in Sri Lanka with 1 year outcome : challenges for the future

Case Report: Omadacycline in the treatment of macrolide-unresponsive Mycoplasma pneumoniae pneumonia in an adolescent patient

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