Analysis of Common Respiratory Infected Pathogens in 3100 Children after the Coronavirus Disease 2019 Pandemic

Ma, June; Ma, Qingfeng; Wang, Wei; Zeng, Yan; Cui, Xianghua; Wang, Guo-lei; Liu, Siyu; Wang, Zhen; Xiao, Xuan; Xia, Zu-neng; Zhu, H; Zhu, Chengliang

doi:10.1007/s11596-022-2635-z

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…By contrast, Tang et al reported no significant change of PIV3 positive rate in 2020 compared to 201–2019 in children from 28 days to 15 years old with respiratory tract infections in Suzhou, Jiangsu Province and Li et al found the positive rate of PIV was higher in September to December 2020 (during the COVID‐19 epidemic) than that in September to December 2019 (before the COVID‐19 epidemic) in Shenzhen, Guangdong Province 19,20 . In a study conducted by Ma et al, an increased positive rate of PIV1 and decreased positive rate of PIV2 and PIV3 were observed among 10 918 children younger than 12 years old after the first wave of COVID‐19 epidemic (May 1–December 31, 2020) compared to that before COVID‐19 epidemic (September 1–December 31, 2018 and May 1–August 31, 2019) in Wuhan, Hubei Province 28 . Different prevalence characteristics were observed in our study, which might due to the different periods of data collection and stage division and the sample size.…”

Section: Discussionmentioning

confidence: 95%

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Dynamics of parainfluenza virus among hospitalized children with acute respiratory tract infection under two‐child policy and COVID‐19 pandemic in Hubei Province, China, 2014–2022

Yi¹,

Zhang

Wang

et al. 2023

Journal of Medical Virology

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To analyze changes in the detection of parainfluenza virus (PIV) in children hospitalized with acute respiratory tract infection (ARTI) during 2014-2022 in Hubei Province, and explore the impact of the universal two-child policy and the public health measures against COVID-19 epidemic on the prevalence of PIV in China. The study was conducted at the Maternal and Child Health Hospital of Hubei Province. Children aged <18 years with ARTI admitted from January 2014 to June 2022 were enrolled. The infection of PIV was confirmed by the direct immunofluorescence method in nasopharyngeal specimens. Adjusted logistic regression models were used to analyze the influence of the universal two-child policy implementation and public health measurements against COVID-19 on PIV detection. Totally 75 128 inpatients meeting the criteria were enrolled in this study from January 2014 to June 2022 with an overall PIV positive rate of 5.5%. The epidemic seasons of PIV prevalence lagged substantially in 2020. A statistically significant higher positive rate of PIV was observed in 2017-2019 compared to that in 2014-2015 (6.12%vs 2.89%, risk ratio = 2.12, p < 0.001) after the implementation of the universal two-child policy in 2016. A steep decline occurred in PIV positive rate during the COVID-19 epidemic in 2020 (0.92% vs 6.92%, p < 0.001) and it rebounded during the regular epidemic prevention and control period in 2021-2022 (6.35%, p = 0.104). In Hubei Province, the implementation of the universal two-child policy might have led to an increase of PIV prevalence, and public health measures during the COVID-19 epidemic might have influenced the fluctuation in PIV detection since 2020.

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Section: Discussionmentioning

confidence: 95%

“…In our study, we found a decreased positive rate of PIV1-3 during Province. 28 There were some limitations in this study. First, the data were obtained from a single center, which limited the elucidation in the whole Hubei province.…”

Section: Impact Of the Covid-19 Epidemic On The Prevalence Of Pivmentioning

confidence: 90%

Dynamics of parainfluenza virus among hospitalized children with acute respiratory tract infection under two‐child policy and COVID‐19 pandemic in Hubei Province, China, 2014–2022

Yi¹,

Zhang

Wang

et al. 2023

Journal of Medical Virology

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“…The most common respiratory diseases associated with HPIV include bronchopneumonia, bronchitis, pertussis syndrome and bronchiolitis [20]. HPIV1 infection was most likely to cause bronchopneumonia, with acute laryngitis, bronchitis, and upper respiratory tract infection following [21]. Bronchopneumonia was the most frequent HPIV3 infection, followed by pertussis syndrome, bronchitis, and bronchiolitis.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological and Clinical Characteristics of Human Parainfluenza Virus Infection in Children of Xianyang Children's Hospital in 2022

Ming

Wang²,

Wang

et al. 2023

AJPR

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The incidence of HPIV infection in children is on the rise, particularly following the emergence of SARS-CoV-2, which presents a potential risk to the health of children. Objective: This study aims to investigate the epidemiological and clinical features of human parainfluenza virus (HPIV) in children admitted to Xianyang Children's Hospital (Xianyang Caihong Hospital) from January 2022 to December 2022. Methods: Out of the 5873 cases of hospitalised children, the ones which had HPIV as the only pathogen and were non-standard cases were excluded, and the rest were analysed for their clinical characteristics, based on the six nucleic acids kits used to detect HPIV in respiratory tract viruses. Results: Among 5873 cases of Nasopharyngeal swab specimens, there were 795 cases of HPIV antigen positive, of which 794 cases of HPIV3（13.52%, 3 cases of HPIV1（0.05%; There were 472 males (13.92%) and 325 females (13.09%) in them(χ2 =0.381, P=0.362).The infection rates in spring, summer, autumn and winter were 8.03%, 55.71%, 28.48% and 7.78%, respectively, and the difference of pairwise comparison were statistically significant (χ2=539.158, P=0).There were 318 cases (19.51%) in infant group and 164 cases (10.86%) in children group (χ2=45.118, P=0). With HPIV as the sole pathogen including 363 cases of bronchopneumonia, 237 cases of bronchitis, 8 cases of pertussis syndrome, 84 cases of bronchiolitis. Conclusion: ⑴. During the period of January to December 2022, Xianyang Children's Hospital has seen a high prevalence of HPIV, a virus causing lower respiratory tract infection, especially HPIV3. ⑵.No statistical evidence showed a difference between men and women in terms of high morbidity during spring and summer, which was more common among infants and young children. ⑶. Among children infected with HPIV, the four most common respiratory illnesses are bronchopneumonia, bronchitis, pertussis syndrome, and bronchiolitis. After undergoing symptomatic treatment, most children showed marked improvement. It is imperative to gain a thorough understanding of HPIV infections in children, enabling timely prevention and symptomatic treatment, identifying critical and serious illnesses, and reducing morbidity and mortality.

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“…In addition, influenza A and B viruses, adenovirus and metapneumovirus were not identified. This may be due to their low frequency in respiratory infections during the period of the COVID-19 pandemic, as presented in several scientific papers [ 16 , 19 , 36 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

High Incidence of Respiratory Syncytial Virus in Children with Community-Acquired Pneumonia from a City in the Brazilian Pre-Amazon Region

Fontes

Ferreira²,

Ribeiro

et al. 2023

Viruses

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Introduction: Although fewer children have been affected by the severe form of the coronavirus disease 2019 (COVID-19), community-acquired pneumonia (CAP) continues to be the leading global cause of child hospitalizations and deaths. Aim: This study investigated the incidence of respiratory syncytial virus (RSV) as well its subtypes (RSV A and B), adenovirus (ADV), rhinovirus (HRV), metapneumovirus (HMPV), coronavirus (NL63, OC43, 229E and HKU1), parainfluenza virus subtypes (PI1, PI2 and PI3), bocavirus and influenza A and B viruses (FluA and FluB) in children diagnosed with CAP during the COVID-19 pandemic. Methods: A total of 200 children with clinically confirmed CAP were initially recruited, of whom 107 had negative qPCR results for SARS-CoV-2 and were included in this study. Viral subtypes were identified using a real-time polymerase chain reaction in the nasopharyngeal swab samples. Results: Viruses were identified in 69.2% of the patients. RSV infections were the most frequently identified (65.4%), with type RSV B being the most prevalent (63.5%). In addition, HCoV 229E and HRV were detected in 6.5% and 3.7% of the patients, respectively. RSV type B was associated with severe acute respiratory infection (ARI) and a younger age (less than 24 months). Conclusions: New strategies for preventing and treating viral respiratory infections, particularly RSV infections, are necessary.

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Analysis of Common Respiratory Infected Pathogens in 3100 Children after the Coronavirus Disease 2019 Pandemic

Cited by 7 publications

References 20 publications

Dynamics of parainfluenza virus among hospitalized children with acute respiratory tract infection under two‐child policy and COVID‐19 pandemic in Hubei Province, China, 2014–2022

Dynamics of parainfluenza virus among hospitalized children with acute respiratory tract infection under two‐child policy and COVID‐19 pandemic in Hubei Province, China, 2014–2022

Epidemiological and Clinical Characteristics of Human Parainfluenza Virus Infection in Children of Xianyang Children's Hospital in 2022

High Incidence of Respiratory Syncytial Virus in Children with Community-Acquired Pneumonia from a City in the Brazilian Pre-Amazon Region

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