Analysis of Common Single Nucleotide Polymorphisms in Complex Regional Pain Syndrome: Genome Wide Association Study Approach and Pooled DNA Strategy

Janicki, Piotr K.; Alexander, Guillermo M.; Eckert, Jill M.; Postuła, Marek; Schwartzman, Robert J.

doi:10.1093/pm/pnw133

Cited by 21 publications

(10 citation statements)

References 20 publications

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“…By contrast, in another study, no differences in DNA singlenucleotide polymorphisms (SNPs) were found between patients with CRPS and unspecified controls 63 . A large number of SNPs (>200,000) were analysed, but no difference passed the statistical threshold after Bonferroni correction.…”

Section: Diagnostic Features and Biomarkersmentioning

confidence: 85%

Complex regional pain syndrome — phenotypic characteristics and potential biomarkers

et al. 2018

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Complex regional pain syndrome (CRPS) is a pain condition that usually affects a single limb, often following an injury. The underlying pathophysiology seems to be complex and probably varies between patients. Clinical diagnosis is based on internationally agreed-upon criteria, which consider the reported symptoms, presence of signs and exclusion of alternative causes. Research into CRPS biomarkers to support patient stratification and improve diagnostic certainty is an important scientific focus, and recent progress in this area provides an opportunity for an up-to-date topical review of measurable disease-predictive, diagnostic and prognostic parameters. Clinical and biochemical attributes of CRPS that may aid diagnosis and determination of appropriate treatment are delineated. Findings that predict the development of CRPS and support the diagnosis include trauma-related factors, neurocognitive peculiarities, psychological markers, and local and systemic changes that indicate activation of the immune system. Analysis of signatures of non-coding microRNAs that could predict the treatment response represents a new line of research. Results from the past 5 years of CRPS research indicate that a single marker for CRPS will probably never be found; however, a range of biomarkers might assist in clinical diagnosis and guide prognosis and treatment.

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Section: Diagnostic Features and Biomarkersmentioning

confidence: 85%

Complex regional pain syndrome — phenotypic characteristics and potential biomarkers

et al. 2018

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“…A conflicting study in 2016 looked at >200 000 single nucleotide polymorphisms between CRPS patients and control groups, and found no significant difference in expression between the two. 30 More investigation is needed to determine if there is a genetic link to developing CRPS.…”

Section: Genetic Influencementioning

confidence: 99%

Complex regional pain syndrome: a narrative review for the practising clinician

Shim

Rose

Halle

et al. 2019

British Journal of Anaesthesia

160

152

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Complex regional pain syndrome (CRPS) is a life-altering condition that usually affects the extremities after a trauma or nerve injury. The physiologic changes that occur as a result of the inciting injury are complex, as the name of the syndrome implies. The pain and disability associated with CRPS often lead to psychological co-morbidities that create a vicious cycle of pain, isolation, and depression. We review recent developments in the understanding of CRPS and advancements in management of this syndrome. Further research in targeting specific mechanisms involved in the pathophysiology of CRPS should lead to prevention of this condition.

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“… 74 Associations with known gene polymorphisms have been described in smaller studies but could not be replicated in larger cohorts. 44 As long as we do not have biomarkers for subgrouping, the detection of genetic factors will remain difficult. Furthermore, association studies need high numbers, but CRPS is a rare disease.…”

Section: Pathophysiology Of Complex Regional Pain Syndromementioning

confidence: 99%

Complex regional pain syndrome–up-to-date

Birklein¹,

Dimova²

2017

PR9

111

101

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Analysis of Common Single Nucleotide Polymorphisms in Complex Regional Pain Syndrome: Genome Wide Association Study Approach and Pooled DNA Strategy

Abstract: Despite the fact that we interrogated about 83% of all of common SNPs in the human genome, we did not find evidence that any of the investigated common SNPs may be associated with CRPS phenotype.

Cited by 21 publications

References 20 publications

Complex regional pain syndrome — phenotypic characteristics and potential biomarkers

Complex regional pain syndrome — phenotypic characteristics and potential biomarkers

Complex regional pain syndrome: a narrative review for the practising clinician

Complex regional pain syndrome–up-to-date

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