The construction industry has a high accident rate worldwide. Because of these negative figures, there are numerous studies by prestigious authors about how to measure the levels of safety and health in construction through indicators. These indicators can be classified based on the following categories: a) Accidents recorded b) Risk assessment, c) Workload, d) Health and safety training, e) Perception of safety and health and f) Health and safety management. However, despite the importance of indicators as a preventive tool, no studies have been found regarding the most appropriate indicators to measure the degree of implementation of the concept of Prevention through Design in civil engineering construction projects. The purpose of this paper is to analyze the main existing indicators to quantify the levels of safety and health in construction, and based on this analysis to propose and validate indicators to measure the Prevention through Design in civil engineering projects, using the staticized groups methodology. The information provided by the new proposed indicators is useful for improving safety levels in construction companies.