Analysis of Coronary Plaque Morphology by 64-Multislice Computed Tomography Coronary Angiography and Calcium Scoring in Patients with Type 2 Diabetes Mellitus

Benedek, Theodora

doi:10.4183/aeb.2011.59

Cited by 11 publications

(7 citation statements)

References 14 publications

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“…The fact that right coronary lesions present larger volumes and larger amounts of intracoronary thrombi has been described by other studies. [31][32][33][34][35] However, according to our knowledge, this is the first study describing a clear difference of vulnerability features in relation to anatomic location in the left versus right coronary tree, suggesting that the right coronary artery is more predisposed to the vulnerabilization process of the atheromatous plaques, which can…”

Section: Discussionmentioning

confidence: 99%

Morphological Features and Plaque Composition in Culprit Atheromatous Plaques of Patients with Acute Coronary Syndromes

Nyulas

Márton

Rus

et al. 2018

Journal of Cardiovascular Emergencies

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Background: The independent role of each plaque feature in relation to plaque vulnerability is still the subject of ongoing research. This study aimed to compare the morphologic characteristics of vulnerable atheromatous coronary plaques with the ones of stable, non-vulnerable plaques, and in plaques with different locations in the coronary tree, in order to identify the most relevant imaging-based biomarkers associated with coronary plaque vulnerability. Material and methods: This was a prospective observational, non-randomized study that included 50 patients with unstable angina who underwent computed tomography angiography for assessment of the entire coronary artery tree followed by complex morphologic analysis of all lesions, divided into two groups: group 1 – 25 patients with vulnerable plaque (VP) and group 2 – 25 age- and gender-matched patients with non-vulnerable plaque (NVP). Results: Lesions with a stenosis degree >70% were significantly longer than those with a stenosis degree <70% (8.27 ± 2.74 mm vs. 5.56 ± 4.11 mm, p = 0.04). VP presented significantly higher values of plaque thickness (p = 0.0005), plaque burden (p = 0.0004), and higher total plaque volume (p = 0.0005) than NVP. The remodeling index was not significantly different between the groups (p = 0.6), but the eccentricity index was (0.24 ± 0.14 compared to 0.14 ± 0.17, p = 0.023). Linear regression analysis revealed a significant correlation between plaque burden and plaque components in VP (r = 0.76, p <0.0001 for necrotic core; r = 0.62, p = 0.0008 for fibro-fatty tissue; and r = 0.5, p = 0.01 for fibrotic tissue volume). Culprit plaques located in the right coronary artery presented significantly larger plaque burden volumes (91.17 ± 4.88 mm3 vs. 83.35 ± 8.47 mm3, p = 0.04), larger volumes of necrotic core (82.03 ± 47.85 mm3 vs. 45.84 ± 43.72 mm3, p = 0.02) and fibrofatty tissue (53.23 ± 31.92 mm3 vs. 23.76 ± 20.90 mm3, p = 0.02) than the ones situated in the left coronary artery. Conclusions: VPs from the culprit lesions exhibit a different phenotype than non-vulnerable ones, and vulnerability features are present in a significantly larger extent in VPs from the right coronary artery as compared to those from the left coronary artery.

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Section: Discussionmentioning

confidence: 99%

Morphological Features and Plaque Composition in Culprit Atheromatous Plaques of Patients with Acute Coronary Syndromes

Nyulas

Márton

Rus

et al. 2018

Journal of Cardiovascular Emergencies

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“…Computed tomography calcium scoring is a safe, rapid and new non-invasive method and screening tool for detecting calcium in the coronary arteries. Th e Agatston Score usually serves for CT quantifi cation of the exact amount of coronary calcium accumulation, on the basis of the area and the CT density of calcifi ed lesions [8]. Clinically, coronary calcium scoring can be used as a predictor of future cardiovascular events, as demonstrated in several international trials, independently of standard risk factors, and enhance Framingham risk stratifi cation categories.…”

Section: Discussionmentioning

confidence: 99%

Correlations Between Severity of Coronary Calcification and Impairment of Left Ventricular Ejection Fraction

Suciu

Benedek

Beáta

et al. 2013

Acta Medica Marisiensis

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Introduction: 64 multislice CT angiography is a recently introduced imaging technique, increasingly being used as a tool to show the coronary arteries in three-dimensional visualization. One of the advantages of this method is the ability to estimate the degree of calcification of atheromatous plaques via coronary calcium score calculation, which correlates with the severity score of ateromatous systemic burden. The aim of this study was to evaluate the relationship between the severity of coronary calcification, expressed by calcium score, and the left ventricular ejection fraction (LVEF). Material and methods: This retrospective study included 81 patients with symptoms of angina and ECG modifications (at rest or during exercise). Echocardiography and 64 multislice CT angiography were performed in all patients to assess the LVEF and Ca scoring. Results: Calcium score was lower than 100 in 62 patients (50.22%), between 100 and 400 in 11 patients (8.91%), and higher than 400 in 8 patients (6.48%). Mean LVEF was 53.52%, 17 patients having an LVEF of less than 50%. In patients with calcium score less than 100, the corresponding ejection fraction was normal: 55.29%, while in coronary arteries with extensive calcifications (calcium score > 400), the LVEF was significantly lower, 50.5% (p = 0.004). Conclusions: High Calcium score is positively correlated with LVEF reduction, and a high value for calcium score indicates an increased probability of reduced left ventricular ejection fraction

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“…Diabetes mellitus (DM) is associated with an increased risk for cardiovascular disease (1)(2) Medicana International Ankara Hospital -Cardiology, 2 Department of Cardiology, Private Akay Hospital, 3 …”

Section: Introductionmentioning

confidence: 99%

Impaired Heart Rate Recovery in Patients with Impaired Glucose Tolerance

Celebi¹

2014

Acta Endo (Buc)

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Background. Heart rate recovery after exercise is a predictor of mortality that is thought to reflect autonomic imbalance. The association between heart rate recovery and prediabetic stages is unclear.Aim. To evaluate the heart rate recovery in patients with diabetes and prediabetes.Patients and Methods. Thirtyfive patients with impaired fasting glucose, 32 patients with impaired glucose tolerance, and 34 patients with diabetes mellitus were included. The control group consisted of 30 healthy individuals. All study participants underwent a maximal graded exercise test, and heart rate recovery was calculated by subtracting the 1 st , 2 nd and 3 rd minute heart rates from the maximum heart rate achieved during the stress testing.Results. The 1 st , 2 nd and 3 rd minute heart rate recovery values of the diabetes mellitus, impaired glucose tolerance and impaired fasting glucose groups were significantly lower than that of the control group. For the 1 st minute, heart rate recovery values of the diabetes mellitus patients were significantly lower than that of the control group (19.8±9.4 vs. 25.4±9.9, p<0.001) and the impaired fasting glucose group (19.8±9.4 vs. 22.1±9.3, p<0.01), and the 1 st minute heart rate recovery of the diabetes mellitus patients was similar to that of the impaired glucose tolerance group (19.8±9.4 vs. 20.7±5.8, p=0.88). Similar results were obtained in the 2 nd and 3 rd minute heart rate recovery measurements.The heart rate recovery values of the impaired fasting glucose were significantly higher than those of the diabetes mellitus and impaired glucose tolerance patients. In comparing the impaired glucose tolerance and diabetes mellitus groups in terms of heart rate recovery values, there was no significant difference.

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Analysis of Coronary Plaque Morphology by 64-Multislice Computed Tomography Coronary Angiography and Calcium Scoring in Patients with Type 2 Diabetes Mellitus

Cited by 11 publications

References 14 publications

Morphological Features and Plaque Composition in Culprit Atheromatous Plaques of Patients with Acute Coronary Syndromes

Morphological Features and Plaque Composition in Culprit Atheromatous Plaques of Patients with Acute Coronary Syndromes

Correlations Between Severity of Coronary Calcification and Impairment of Left Ventricular Ejection Fraction

Impaired Heart Rate Recovery in Patients with Impaired Glucose Tolerance

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