Analysis of cortical cell polarity by imaging flow cytometry
Jesper H. Jespersen,
Andras Harazin,
Anja B. Bohn
et al.
Abstract:Metastasis is the main cause of cancer‐related death and therapies specifically targeting metastasis are highly needed. Cortical cell polarity (CCP) is a prometastatic property of circulating tumor cells affecting their ability to exit blood vessels and form new metastases that constitute a promising point of attack to prevent metastasis. However, conventional fluorescence microscopy on single cells and manual quantification of CCP are time‐consuming and unsuitable for screening regulators. In this study, we d… Show more
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