Analysis of Corticosteroids

Fraser, Robert; Gower, D. B.; Honour, John W.; Ingram, M; Kicman, Andrew T.; Makin, H. L. J.; Stewart, Paul M.

doi:10.1023/b135931_5

Cited by 11 publications

(17 citation statements)

References 416 publications

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“…Thus, four deaths and up to 800 people were injured, after using weight-loss supplements containing hidden quantities of the untested drug n-nitroso-fenfl uramine (Lau, 2004). Skin-lightening creams containing mercury were responsible for hundreds of poisoning cases (Oliveira, Foster, Savill, Syme & Taylor, 1987), with creams containing hydroquinone and corticosteroids also causing many harms (Fraser et al, 2010 Note. 1 A number of human enhancement drugs are also legitimate medicines, which have been tested and approved at appropriate dosages for specific conditions.…”

Section: The Harms Associated With Human Enhancement Drugsmentioning

confidence: 99%

Drogas potenciadoras para la búsqueda de la perfección

2012

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Section: The Harms Associated With Human Enhancement Drugsmentioning

confidence: 99%

Drogas potenciadoras para la búsqueda de la perfección

2012

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“…cortisol) and have important effects on a variety of metabolic events, including glucose and protein metabolism. The overall effect is to increase the blood glucose level by stimulating hepatic synthesis of glucose from amino acids [1]. Nowadays, several exogenous corticosteroids (prednisolone, dexamethasone, betamethasone, methylprednisolone) are authorized for therapy in both human and veterinary practices.…”

Section: Introductionmentioning

confidence: 99%

“…They affect glucose utilization, fat metabolism, and bone development and are commonly used in the treatment of allergic reactions. They are also used to reduce inflammation [1][2][3]. Exogenous corticosteroids, however, suppress the body's natural production of corticosteroids by inhibiting the release of the hormone, adrenorticotropic.…”

Section: Introductionmentioning

confidence: 99%

“…Exogenous corticosteroids, however, suppress the body's natural production of corticosteroids by inhibiting the release of the hormone, adrenorticotropic. In the EU, the application of corticosteroids for food-producing animal therapy has been controlled, because corticosteroids have growth promoter properties, too [1][2][3]. Therefore, a minimum required performance limit (MRPL) concentration of 2 g/L has been set for dexamethasone in urine by EU [4].…”

Section: Introductionmentioning

confidence: 99%

“…Hence, there is a need to develop analytical methods for the determination of corticosteroids in food and environmental samples to protect consumers from the harmful effects of residues. Liquid chromatographic (LC) methods have been proven to be the most suitable techniques in corticosteroid analysis [1]. Although gas chromatographic (GC) separation can also be used for corticosteroid separation; it requires a time-consuming derivatization step [8,9] that makes it less preferable.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Simultaneous determination of eight corticosteroids in bovine tissues using liquid chromatography–tandem mass spectrometry

Tölgyesi

Sharma

Fekete

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Journal of Chromatography B

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Desperately seeking stress: A pilot study of cortisol in archaeological tooth structures

Quade

Chazot

Gowland

2020

American J Phys Anthropol

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Objectives: Cortisol is a glucocorticoid hormone produced through activation of the hypothalamic pituitary adrenal axis. It is known as the "stress hormone" for its primary role in the body's stress response and has been the focus of much modern clinical research. Within archaeology, only a few studies have analyzed cortisol in human remains and these have been restricted to hair (Webb et al., 2010; Webb, White, van Uum, & Longstaffe, 2015a; Webb, White, van Uum, & Longstaffe, 2015b). This study examines the utility of dentine and enamel, which survive well archaeologically, as possible reservoirs for detectable levels of cortisol. Materials and methods: Then, 69 teeth from 65 individuals from five Roman and Post-Roman sites in France were tested via competitive enzyme-linked immunosorbent assay (ELISA) to assess and quantify the cortisol concentrations present within tooth dentine and enamel. Results: In both tooth dentine and enamel, detectable concentrations of cortisol were identified in multiple teeth. However, concentrations were low and not all teeth yielded results that were measurable through cortisol ELISA. Differences in cortisol values between dentine and enamel could suggest different uptake mechanisms or timing. Discussion: These results suggest that cortisol is incorporated within tooth structures and merits further investigation in both modern and archaeological contexts. Analysis of the results through liquid chromatographic-mass spectrometry would verify current results and might yield values that could be better integrated with published cortisol studies. Future studies of cortisol in tooth structures would greatly expand the research potential of cortisol in the past and could have implications for studies of human stress across deep time.

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Analysis of Corticosteroids

Cited by 11 publications

References 416 publications

Drogas potenciadoras para la búsqueda de la perfección

Drogas potenciadoras para la búsqueda de la perfección

Simultaneous determination of eight corticosteroids in bovine tissues using liquid chromatography–tandem mass spectrometry

Desperately seeking stress: A pilot study of cortisol in archaeological tooth structures

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