Analysis of Cutaneous Lymphomas in a Medical Center in Bahia, Brazil

Abstract

The frequencies observed here are close to those observed in Peru but different from those of European countries. Unfortunately, the World Health Organization/European Organization of Research and Treatment of Cancer classification does not include primary cutaneous ATL.

Oral and cutaneous lymphomas other than mycosis fungoides and sézary syndrome in a mexican cohort: Recategorization and evaluation of international geographical disparities

“…[30] While only one-third of the non-MF/SS PCL in our laboratory could be properly reclassified due to limited tissue availability, the frequency of lymphoma variants seems to differ in some aspects from both European/USA and South American registries. [282930313233343536373839404142] As in other international cohorts, non-MF/SS PC-TCL outnumbered PC-BCL. The former was led by CD30+ lymphoprolifeative disorders, in accordance with other international reports,[2829303132333435363738394041] followed closely by EBV-related NK/T-cell malignancies (PC-NK/TCL and HVLLPD), commonly reported in Asia and Central America but exceptionally in Europe and the USA.…”

“…To date, only a handful of studies on the descriptive epidemiology of PCL have been conducted in Latin America (mainly Brazil, Peru, and Argentina),[31323334353637383940] and not, to the best of our knowledge, in Central and Northern Latin America where ethnicity and incidence of EBV and human T-cell leukemia virus I/II (HTLV-I/II) seropositivity substantially differ.…”

Adult T-cell leukemia/lymphoma

“…31 In Bahia, among the cases of primary cutaneous T-cell lymphoma, 26.4% correspond to primary cutaneous ATL, while secondary ATL corresponds to 66.7%. 17 This data shows that ATL is frequent in Brazil.…”

“…It is important to include a macrophage marker in the immunophenotype, such as CD68, to differentiate the macrophages of large lymphocytes in cases with MF pattern. 17 In large-cell lymphomas, the CD30 and ALK markers are also important. The cases of ATL with ALCL pattern recorded in Bahia were CD30 and ALK-.…”

“…15 The risk of carriers of the virus developing ATL during their lifetime is 6 to 7% in men and 2 to 3% in women, usually after a long latency period (20 to 30 years). 16 ATL corresponds to around 33% of the cases of cutaneous T-cell lymphoma at a reference service in Bahia, 17 and occurs predominantly in those of African descent. 7 Although this disease is considered aggressive, cases with very long progression have been recorded.…”