Anatomical ACL replacement with medial portal drilling and footprint reconstruction is the technique of choice for patients with symptomatic instability after an ACL rupture (non-coper). The gold standard is the anatomic single-bundle reconstruction with mid-position placement of the tunnel. For patients with a large attachment area, a double-bundle technique could be indicated. Graft options for anatomical ACL reconstruction are the hamstrings, patellar tendon, or the quadriceps tendon with or without bone blocks. Graft choice depends on the individual demands and needs of the patient. A large group of patients can be treated successfully by all three autografts or by nonirradiated allografts. Some subgroups, however, may profit from a specific graft choice. Age, gender, activity, sports, profession, and religious habits should be considered.