Analysis of d-penicillamine by high-performance liquid chromatography with glassy carbon electrochemical detection

Shaw, Ian C.; McLean, A. E. M.; Boult, Cherie H.

doi:10.1016/s0378-4347(00)84363-7

Cited by 20 publications

(2 citation statements)

References 10 publications

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“…A mean concentration for total reduced D-penicillamine of 16·7 umol/L given by Shaw et al, 17 for samples removed between 8 and 9 h after a dose of 125 mg would appear high on comparison with other published data. In Jefferies' study11 values of 7 to 78ltmoVL for plasma total reduced D-penicillamine and 0 to 1 umol/L for free D-penicillamine were obtained on samples taken at random times after dose ingestion.…”

Section: Plasma D-penicillamine 189mentioning

confidence: 62%

Identification of Factors Limiting the Accurate Measurement of Plasma D-Penicillamine in Rheumatoid Arthritis Patients

Webb¹,

Richardson²,

Haslock³

1988

Ann Clin Biochem

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SUMMARY. Free and total reduced concentrations of D-penicillamine have been measured in the plasma of rheumatoid arthritis patients by HPLC and electrochemical detection. A reverse-phase ion-pair separation in conjunction with a dual porous graphite electrode satisfied the requirements of robustness, sensitivity, selectivity and suitable retention time. Plasma levels measured between 1·5 and 3 h after an oral dose, were <0·3 to 57·6 umol/L and 0·6 to 85·0 umol/l, (n=26) for free and total reduced drug concentrations, respectively. Sources of error in the accurate measurement of peak plasma D-penicillamine levels were identified as oxidative loss and alteration in the free to protein-bound ratio in the period following sample collection.

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Section: Plasma D-penicillamine 189mentioning

confidence: 62%

Identification of Factors Limiting the Accurate Measurement of Plasma D-Penicillamine in Rheumatoid Arthritis Patients

Webb¹,

Richardson²,

Haslock³

1988

Ann Clin Biochem

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“…Several methods have been reported for the analysis of D-Penicillamine in both pharmaceutical preparations and biological samples. These methods include colorimetry [3][4][5][6][7][8][9][10], fluorimetry [11], chromatography [12][13][14][15][16][17][18][19], flow injection analysis [20][21][22], electrophoresis [23][24][25], potentiometry [26], voltammetry [27][28][29] and NMR spectrometry [30]. Due to the lack of chromophore and or auxochrome in D-penicillamine molecule, direct spectrophotometry cannot be used for its analysis.…”

Section: Introductionmentioning

confidence: 99%

A New Spectrophotometric Method for Determination of Penicillamine in Pharmaceutical Formulation Using 1, 2-naphthoquine-4-sulfonate (NQS)

Elbashir¹,

Awad²

2013

J Pharmacovigilance

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A rapid, simple and sensitive method for the determination of D-Penicillamine using sodium 1,2-naphthoquine-4-sulfonate (NQS) has been developed. The method is based on the fact that a brown product can be formed by the reaction between D-Penicillamine and sodium NQS in a buffer solution of a pH 12.0. Beer's law is obeyed in the range 10-30 µg/mL of D-Penicillamine at maximum wavelength of 425 nm. The linear regression equation of the calibration curve is A=0.1684+0.01624C (µg/mL), with a linear regression correlation coefficient of 0.997. The detection limit is 3.12 µg/mL and the recovery rate is in the range of 99.21-108.2%. The method has been successfully applied to the determination of D-Penicillamine in pharmaceutical formulation.

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Elektrochemische Detektion in Fließsystemen

Ernons

Jokuszies

1988

Zeitschrift fuer Chemie

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In the review principles and analytical applications of conductometric, potentiometric, voltammetric and coulometric detection in streaming solutions are described, with the emphasis on dynamic interfacial techniques. Sensitivity, detection limit, linear dynamic range, response time, selectivity and stability are discussed. Favourable detector cell designs are described focussing on hydrodynamic, electrochemical and stability characteristics. Practical applications of amperometric detectors are summarized. Finally most recent developments and further trends in detector research are outlined.

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Analysis of d-penicillamine by high-performance liquid chromatography with glassy carbon electrochemical detection

Cited by 20 publications

References 10 publications

Identification of Factors Limiting the Accurate Measurement of Plasma D-Penicillamine in Rheumatoid Arthritis Patients

Identification of Factors Limiting the Accurate Measurement of Plasma D-Penicillamine in Rheumatoid Arthritis Patients

A New Spectrophotometric Method for Determination of Penicillamine in Pharmaceutical Formulation Using 1, 2-naphthoquine-4-sulfonate (NQS)

Elektrochemische Detektion in Fließsystemen

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