Creep processes may relax part of the tectonic stresses in active faults, either by continuous or episodic processes. The aim of this study is to obtain a better understanding of these creep mechanisms and the manner in which they change in time and space. Results are presented from microstructural studies of natural samples collected from San Andreas Fault Observatory at Depth borehole drilled through the San Andreas Fault, which reveal the chronology of the deformation within three domain types. (i) A relatively undeformed zone of the host rock reflects the first step of the deformation process with fracturing and grain indentations showing the coupling between fracturing and pressure solution. (ii) Shear deformation development that associates fracturing and solution cleavage processes leads to profound changes in rock composition and behavior with two types of development depending on the ratio between the amount of dissolution and deposition: abundant mineral precipitation strengthens some zones while pervasive dissolution weakens some others, (iii) zones with mainly dissolution trended toward the present-day creeping zones thanks to both the passive concentration of phyllosilicates and their metamorphic transformation into soft minerals such as saponite. This study shows how interactions between brittle and viscous mechanisms lead to widespread transformation of the rocks and how a shear zone may evolve from a zone prone to earthquakes and postseismic creep to a zone of steady state creep. In parallel, the authors discuss how the creeping mechanism, mainly controlled by the very low friction of the saponite in the first 3-4 km depth, may evolve with depth.