Analysis of dexmedetomidine on the quality of awakening during neurosurgery

Abstract

Dexmedetomidine has a dose-dependent sedative and analgesic effect. To further evaluate the wake-up quality of dexmedetomidine in patients undergoing neurosurgery, a meta-analysis of dexmedetomidine in a randomized controlled trial of general anesthesia was performed. Firstly, an experimental algorithm was proposed, and then the data fusion algorithm was used to conduct randomized controlled trials. The clinical efficacy and safety of dexmedetomidine in the acupuncture of neurosurgical patients were evaluated one by one for quality evaluation and data extraction. The effect of different input variables on the depth of anesthesia was studied by using a multi-data fusion approach. The results show that the data fusion algorithm proposed can effectively connect redundant information and complementary information in multiple data, and estimate the real parameters of the measured object. In addition, data fusion brings great convenience to the design of control algorithms and controllers, and provides an effective basis for system simplification. Experiments have shown that dexmedetomidine is effective and safe in the operation of neurosurgical motor function, and the management of the recovery period is safe and effective. Based on the research, it can provide some reference for the awakening of patients undergoing neurosurgery, and promote the progress and development of medicine.

The effect of dexmedetomidine on wake-up test quality when muscle relaxants are not used: A randomized control trial

“…[ 9 ] In contrast to other sedatives working on the cerebral cortex, DEX is less likely to affect awakening during spinal surgery. [ 6 ]…”

“…In congruence with our findings, Cao et al . [ 6 ] found that the DEX group was associated with longer duration of wake-up. On the other hand, the wake-up test quality was found significantly better in the DEX group.…”

“…In line with the current work, previous studies demonstrated that DEX reduced restlessness during the awakening period. [ 6 , 20 - 22 ]…”

“…Cao et al . (2019)[ 6 ] observed that DEX use for spinal surgery anaesthesia significantly improved the recovery quality with the intraoperative DEX pumping led to reduction of the amount of intraoperative sedatives and hindered postoperative anxiety. The sedative effect of DEX is explained by its nature as an α2 adrenergic receptor agonist.…”

“…[ 5 ] DEX provides a neuropharmacological state that simulates the natural sleep pathways. Although the DEX effect on the intraoperative wake-up test quality has been assessed,[ 6 ] its safety and effectiveness are still controversial.…”