The middle Permian Maokou Formation in the Longnüsi area in the central Sichuan Basin is currently a key formation for exploration and development. The evaluation of the current in situ stress in this area is of great significance for fracture prediction, well pattern deployment, drilling and construction, and fracturing stimulation. This study clarifies the current direction and magnitude distributions of the in situ stress by evaluating the Maokou Formation in the Longnüsi area using finite-element numerical simulation, acoustic emission experiments, and logging data (including data from imaging logging, array acoustic logging, conventional logging, and cross-dipole acoustic logging). Specifically, the current maximum horizontal stress of the Maokou Formation in the Longnüsi area is mainly in the NW‒SE direction, and the stress direction is greatly affected by the local fault zone. The current minimum horizontal stress magnitude of the Maokou Formation obtained by acoustic emission experiments is between 96.29 and 114.36 MPa, the current maximum horizontal stress magnitude is between 126.01 and 145.10 MPa, and the current horizontal stress difference is between 25.59 and 32.58 MPa. The current minimum and maximum horizontal stress magnitudes both decrease from north to south. The current horizontal stress parameters calculated by Huang’s model are not significantly different from those experimentally measured: there is a difference of less than 8% in the current minimum horizontal stress magnitude, a difference of less than 9% in the maximum horizontal stress magnitude, and a difference of less than 15% in the current horizontal stress difference. Therefore, Huang’s model has good applicability in terms of calculating the current horizontal stresses in the Longnüsi area. The current horizontal stress parameters, which are numerically simulated with the finite-element method, are also not much different from those experimentally measured: there is a difference of less than 11% in the current minimum horizontal stress magnitude, a difference of less than 10% in the maximum horizontal stress magnitude, and a difference of less than 20% in the current horizontal stress difference. The numerically simulated current horizontal stress also decreases from north to south. Therefore, the simulated results are highly accurate. This study clarifies the directions and magnitudes of the current in situ stress state of the Maokou Formation in the Longnüsi area of the central Sichuan Basin and provides a basis for the formulation of exploration and development plans for the Maokou Formation reservoir in the study area.