Analysis of domain organization and functional signatures of trypanosomatid keIF4Gs

Das, Supratik

doi:10.1007/s11010-022-04464-7

Cited by 4 publications

(2 citation statements)

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“…eIF4E, eIF4G and eIF4A appear to be conserved in these protozoan parasites (15). We have previously studied the conservation, domain organization and functional signatures of trypanosomatid keIF4Es and keIF4Gs and reported both conservation and divergences (15,27). Here, we have looked at the third component of the eIF4F complex viz eIF4A1 in trypanosomatids and Plasmodiums.…”

Section: Discussionmentioning

confidence: 99%

“…We have earlier studied the domain organization and functional signatures of the trypanosomatid keIF4Es and keIF4Gs (15,27). Although the presence of eIF4A orthologues in Leishmania and Trypanosoma has been known for quite some time and limited studies have been carried out, a comprehensive study of this protein in trypanosomatids has not been carried out.…”

Section: Introductionmentioning

confidence: 99%

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Architecture, domain organization, and functional signatures of trypanosomatid keIF4A1s and Plasmodium peIF4A1s suggest conserved functions

Dadwal,

Das

2023

J Biosci

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Initiation of translation is the rst of the three obligatory steps required for protein synthesis and is carried out by a large number of protein factors called initiation factors in conjunction with ribosomes. One of the key conserved protein factors in eukaryotes that plays a role in this process is eIF4A which has three homologues in humans with eIF4A1 being the primary factor playing a role in translation initiation.eIF4As are members of a family called DEAD-box helicases that carry out different biological functions. eIF4A1s are recruited to translation initiation complexes via association with eIF4G and have ATP binding, ATP hydrolysis, RNA binding and unwinding activities. Plasmodium and trypanosomatids like Leishmania and Trypanosoma are parasites that cause human disease. While mechanistically the function of eIF4A1s in eukaryotes is well understood, the orthologues peIF4A1s and keIF4A1s in Plasmodium and trypanosomatids are not well studied. Here, we have used bioinformatics tools and homology modeling to study the motifs and functional signatures of Plasmodium and trypanosomatid peIF4A1s/ keIF4A1s. We report that inspite of the great divergence in evolution between these parasites and higher eukaryotes there is remarkable conservation of motifs and functional signatures in Plasmodium and trypanosomatid peIF4A1s/ keIF4A1s.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%