Analysis of Doxorubicin and Doxorubicinol in Dried Blood Spot of Breast Cancer Patients for Monitoring the Cardiotoxicity of Doxorubicin

Harahap, Yahdiana; Amalia, Sabrina Nur; Anarta, Aldhi; Ramadhan,

doi:10.22159/ijpps.2020v12i4.36707

Cited by 7 publications

(15 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinical studies have confirmed this issue. Cardiomyopathy, gastrointestinal (GI) side effects and hematological abnormalities result from using DOX alone or in combination with other chemotherapeutic agents in cancer therapy [23][24][25]. Increased level of oxidative stress and subsequent apoptosis induction are responsible for DOX toxicity [26].…”

Section: Introductionmentioning

confidence: 99%

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

et al. 2021

View full text Add to dashboard Cite

Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent has been frequently used for cancer therapy, leading to chemoresistance. Due to dose-dependent toxicity, high concentrations of DOX cannot be administered to cancer patients. Therefore, experiments have been directed towards revealing underlying mechanisms responsible for DOX resistance and ameliorating its adverse effects. Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling is activated to increase levels of reactive oxygen species (ROS) in cells to protect them against oxidative stress. It has been reported that Nrf2 activation is associated with drug resistance. In cells exposed to DOX, stimulation of Nrf2 signaling protects cells against cell death. Various upstream mediators regulate Nrf2 in DOX resistance. Strategies, both pharmacological and genetic interventions, have been applied for reversing DOX resistance. However, Nrf2 induction is of importance for alleviating side effects of DOX. Pharmacological agents with naturally occurring compounds as the most common have been used for inducing Nrf2 signaling in DOX amelioration. Furthermore, signaling networks in which Nrf2 is a key player for protection against DOX adverse effects have been revealed and are discussed in the current review.

show abstract

Section: Introductionmentioning

confidence: 99%

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

et al. 2021

View full text Add to dashboard Cite

show abstract

“… * Test solution and Found using −log [DOX] mol L −1 ** SE (%Error) = %RSD/

. *** The tabulated values of “ t -test” and ‘‘F-test’’ at confidence level p = 0.05 [ 52 ]. …”

Section: Resultsmentioning

confidence: 99%

“…A confirming study was performed by comparing the outcomes by other results obtained from a previously addressed method [ 52 ]. The random detection of plasma samples revealed that the modified DOX-PM-NiO/MgO nanocomposite sensor showed ultrasenstivity for the determination of DOX in bio samples rather than the previously reported method.…”

Section: Resultsmentioning

confidence: 99%

“…Table 6. The results obtained from the determination of DOX in human plasma using modified DOX-PM-NiO/MgONPs coated wire sensor in comparison with a reported method [52].…”

Section: Discussionmentioning

confidence: 99%

“…The outcomes from the determination of DOX in Adriamycin ® injections using fabricated DOX-PM and modified DOX-PM-NiO/MgO nanocomposite coated wire sensors in comparison with a reported method[41]. Test solution and Found using −log [DOX] mol L −1 ** SE (%Error) = %RSD/ √ n. *** The tabulated values of "t-test" and "F-test" at confidence level p = 0.05[52].…”

mentioning

confidence: 99%

See 2 more Smart Citations

New Functionalized Polymeric Sensor Based NiO/MgO Nanocomposite for Potentiometric Determination of Doxorubicin Hydrochloride in Commercial Injections and Human Plasma

Alarfaj

El‐Tohamy

2020

Polymers

View full text Add to dashboard Cite

The ultra-functional potential of nickel oxide (NiO) and magnesium oxide (MgO) nanoparticles (NPs), provides for extensive attention in the use of these metal oxides as a remarkable and electroactive nanocomposite in potentiometric and sensing investigations. This work proposed a new strategy for quantifying doxorubicin hydrochloride (DOX) in pharmaceuticals and human plasma by preparing a NiO/MgO core-shell nanocomposite modified coated wire membrane sensor. Doxorubicin hydrochloride was incorporated with phosphomolybdic acid (PMA) to produce doxorubicin hydrochloride phosphomolybdate (DOX-PM) as an electroactive material in the presence of polymeric high molecular weight poly vinyl chloride (PVC) and solvent mediator o-nitrophenyloctyl ether (o-NPOE). The modified sensor exhibited ultra sensitivity and high selectivity for the detection and quantification of doxorubicin hydrochloride with a linear relationship in the range of 1.0 × 10−11–1.0 × 10−2 mol L−1. The equation of regression was estimated to be EmV = (57.86 ± 0.8) log [DOX] + 723.19. However, the conventional type DOX-PM showed a potential response over a concentration range of 1.0 × 10−6–1.0 × 10−2 mol L−1 and a regression equation of EmV = (52.92 ± 0.5) log [DOX] + 453.42. The suggested sensors were successfully used in the determination of doxorubicin hydrochloride in commercial injections and human plasma.

show abstract

Antitumor activities of carboplatin–doxorubicin–ZnO complexes in different human cancer cell lines (breast, cervix uteri, colon, liver and oral) under UV exposition

Pairoj

Damrongsak

et al. 2021

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

This study aimed to examine the pharmacological profiles of multiple chemo drug candidates in systematic circulation to enhance their specific interactions with five human cancer cell lines. ZnO nanoparticles were successfully bound with chemo drugs via physical adsorption. The drug loading capacity was confirmed by FTIR, whereas the loading efficiency was determined via UV-vis spectrometry. The mean hydrodynamic size increased to 69-82 nm after chemo-drug immobilization via non-covalent interaction with ZnO. Among the nine formulated chemo drugs, the carboplatin (CP)-doxorubicin (DOX)-ZnO complex under UV light irradiation exhibited high sensitivity towards human breast adenocarcinoma cells without affecting human keratinocyte immortal cells with an IC 50 of 0.137 mg/mL, whereas the loading capacity and efficiency of CP-DOX-ZnO were 77.81% and 99.05%, respectively. Fluorescence images confirmed that CP-DOX-ZnO using DOX served as a fluorescence enhancer specifically bound onto the cell membranes, which became almost saturated after 24 h incubation. Carboplatin-DOX-ZnO was possibly endocytosed by cancer cells and was selectively internalized into the target cells; thus, free chemo drug was released in the cytoplasm, which induced acute apoptosis. This resulted in complete inhabitation of growth signal of target cancer cells.

show abstract

Analysis of Doxorubicin and Doxorubicinol in Dried Blood Spot of Breast Cancer Patients for Monitoring the Cardiotoxicity of Doxorubicin

Cited by 7 publications

References 9 publications

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery

New Functionalized Polymeric Sensor Based NiO/MgO Nanocomposite for Potentiometric Determination of Doxorubicin Hydrochloride in Commercial Injections and Human Plasma

Antitumor activities of carboplatin–doxorubicin–ZnO complexes in different human cancer cell lines (breast, cervix uteri, colon, liver and oral) under UV exposition

Contact Info

Product

Resources

About