Flying and driving simulation has encouraged an enormous and growing community in a wide variety of areas such as research centers, driver or pilot training academies, vehicle-testing facilities, amusement parks, and even at home by household enthusiasts, providing carefully integrated visual and perceptual illusions of driving or flying real vehicles. The global research on this subject is explored during the period 2000 to 2019 from an interdisciplinary perspective based on a systematic methodology, providing both new and experienced researchers with broad guidance toward key aspects for further investigations and developments. Emphasis is given to the analysis of the findings and in particular to their applicability, to an extent not attempted earlier, by considering both human and machine aspects.