Analysis of Drugs

Quality assessment of fluoxetine and fluvoxamine pharmaceutical formulations purchased in different countries or via the Internet by 19F and 2D DOSY 1H NMR

“…However, the method can be employed for toxicological studies as FLX and FLV toxic plasma levels are above 1000 g L −1 and 650 g L −1 , respectively [38]. The development of quantitative NMR has been accelerated since about 10 years by the increase of the sensitivity of high-field NMR spectrometers as well as by modern software packages that allow an accurate and precise data processing, and quantitative NMR is now well validated [16,18]. Nevertheless, all the relevant parameters for 19 F NMR recording and data acquisition and processing in order to determine absolute concentrations were taken into account 30 years ago [39,40].…”

“…Two of them were the brand formulations from LILLY (Prozac ® ) and SOLVAY Pharma (Floxyfral ® ), the others were generic drugs from different countries. The declared amounts of the active ingredient in the various Table 1 Commercial formulations of fluoxetin (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) and fluvoxamine (16)(17)(18)(19) All samples, as received, were stored in the dark at ambient temperature and humidity. They were all analysed within expiry dates.…”

“…Reported methods for the determination of FLX and FLV of the spectrum, integration], the area of each NMR peak is directly proportional to the number of corresponding nuclei and thus NMR is a quantitative spectroscopic tool [16][17][18]. Surprisingly, even if both FLX and FLV are fluorinated drugs (Fig.…”

Targeting and Dissolution Characteristics of Bone Forming and Antibacterial Drugs by Harnessing the Structure of Microspherical Shells from Coral Beach Sand

“…In brief, the surface analysis techniques used include the environmental scanning electron microscope (ESEM), the X-ray photoelectron spectrophotometer (XPS), and EDS analysis. The dissolution studies include the development of a new technique using the NMR [24,[29][30][31] and inductively coupled plasma mass spectroscopy (ICP-MS). The cell culture studies undertaken to characterize the samples to test their potential in vivo behavior include the use of SaOS-2, human osteoblast cell line, and U937, human monocyte cell line.…”

“…Since we can coat every individual shell in a biocompatible lipid film, specific cell targeting instructions can be added to the surface. [27][28][29][30][31] This will significantly enhance the therapeutic utility and purpose of this device.…”