Analysis of drugs and personal care products in French source and drinking waters: the analytical challenge and examples of application

Bruchet, A.; Hochereau, C.; Picard, Catherine H.; Decottignies, V.; Rodrigues, J.M.; Janex-Habibi, Marie-Laure

doi:10.2166/wst.2005.0224

Cited by 60 publications

(29 citation statements)

References 4 publications

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“…SVT was also present at all sampling sites at levels ranging from 2.3-16.7 ng/L, and this is the first time that SVT, ATT and BZB were determined in the surface waters in China. Antibiotics have been reported to be prevalent at detectable concentration in surface waters in other regions of the world due to their large usage and continual input into the ecosystem [6,19,36,[42][43][44][45][46][47]. In the present study, the concentration and frequency of detection for antibiotics including quinolone antibiotics (OFX and NOR), macrolide antibiotics (ERY-H 2 O, ROX and AZM) and sulfonamide antibiotics (SMZ, SM1, SDZ and TMP) was generally higher than other selected PhACs, probably due to the abuse of antibiotics in China.…”

Section: Resultsmentioning

confidence: 99%

A Preliminary Study on the Occurrence of Pharmaceutically Active Compounds in the River Basins and Their Removal in Two Conventional Drinking Water Treatment Plants in Chongqing, China

Yan

Zhang

Kang

et al. 2014

CLEAN Soil Air Water

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The occurrence of 21 selected pharmaceutically active compounds (PhACs) in river water was examined; meanwhile the presence and removal of these PhACs at different water treatment steps in two conventional drinking water treatment plants (DWTPs) were evaluated. Monitoring results showed that of all 21 target PhACs, twelve PhACs were ubiquitously detected in water samples from the Yangtze river and its two tributaries (Jialing River and Huaxi stream), whereas alodipine was not found in any river water sample. The concentrations of PhACs detected in Huaxi stream were statistically significantly higher than those found in the Jialing River and the Yangzi River because of the direct discharges of uncontrolled domestic sewage and poultry wastewater and the abuse of PhACs in the rural areas served by the Huaxi stream. An environmental risk assessment of PhACs based on the risk quotient value approach indicated that sulfamethoxazole, ofloxacin and dehydrated erythromycin and clofibric acid had a medium risk, and the mixture of the studied PhACs showed high risk for the aquatic ecosystems. Fourteen out of 21 target PhACs were found in the raw water of the two studied DWTPs with azithromycin having the highest concentration (about 20 ng/L). Following the conventional water treatment processes, the studied PhACs were found to be removed by an average of 54 and 48% in DWTP A and DWTP B, respectively. Among the target PhACs, six and three PhACs were detected in finished water of DWTP B and DWTP A, respectively. This is the first study in southwestern China reporting the presence of PhACs in surface water and drinking water.

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Section: Resultsmentioning

confidence: 99%

A Preliminary Study on the Occurrence of Pharmaceutically Active Compounds in the River Basins and Their Removal in Two Conventional Drinking Water Treatment Plants in Chongqing, China

Yan

Zhang

Kang

et al. 2014

CLEAN Soil Air Water

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“…But due to its inclusion in almost all PCPs and to its massive use, allied to frequent water rinsing of these products after application, a great part of HHCB enters the environment through residual water, and it is expected that 77% of the musks are discharged into the sewer system after used [7]. In fact, HHCB has been found in wastewater treatment plants influents (from 0.029 to 45.4 lg L À1 ) and effluents (from bellow 0.0005 to 13.3 lg L À1 ), and in surface and groundwater (0.00009 to 12.47 lg L À1 ) in several countries of Europe, America and Asia [2,4,5,[7][8][9][10][11][12][13][14], as well as in drinking water from concentrations bellow 0.03 to few lg L À1 [8,15]. HHCB has also been found in sewage sludge of wastewater treatment plants all over the world, from 1.4 to 63 000 lg kg À1 dry weight (dw) [2,4,5,7,[16][17][18][19], and in sediments and suspended matter, from 0.2 to 13 722 lg kg À1 dw [2-4, 18, 19].…”

Section: R Esum Ementioning

confidence: 99%

Human dermal exposure to galaxolide from personal care products

Correia

Cruz

Santos

et al. 2013

Intern J of Cosmetic Sci

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Musks are synthetic fragrances applied on personal care and household products as fixatives, by retarding the release of other fragrances with higher volatility. Galaxolide is the most used polycyclic musk since the 90th decade, and it has been detected in several environmental and biological matrices, particularly in human tissues and fluids. For exposure assessment purposes, large-monitoring data need to be obtained and rapid but reliable analytical techniques are requested. The main objective of this study is to develop and validate a new and fast analytical methodology to quantify galaxolide in personal care products and to apply this method to real matrices like skin care products (creams and lotions), shower products (soap bar), hair care products (shampoo and hair conditioner) and oral care products (toothpaste), to evaluate the human dermal exposure risk. A dispersive solid-phase extraction is proposed, using QuEChERS methodology, followed by HPLC with fluorescence detection. Some extraction parameters were studied, like the ratio of sample/solvent amounts, the homogenization time, the salt addition effect and the used sorbents. The validation parameters of the developed method were the following: a linearity range of 0.005-1.002 mg kg⁻¹ sample, a limit of detection of 0.001 mg kg⁻¹ sample, repeatability between 0.7% and 11.3% (variation coefficient of six standard injections), an intermediate precision of 2.5% (variation coefficient of six independent analysis of the same sample), mean recoveries ranging from 65% (soap bar) to 95% (body cream) and 3% of global uncertainty in most of the working range. The time of analysis, including the extraction steps, is 60 min, allowing a throughput of 4 samples h⁻¹ . Galaxolide was detected in all of the seven analysed products in concentrations ranging from 0.04 ± 0.01 mg kg⁻¹ sample (toothpaste) to 280.78 ± 8.19 mg kg⁻¹ sample (perfumed body cream), which may correspond to a significant estimated daily human dermal exposure of 904 μg day⁻¹.

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“…Biodegradation was estimated using the ultimate survey model incorporated in BIOWIN 4.10 (U.S.EPA, USA). In regard to removal capability by conventional water treatments, nine domestic/international literatures (Ternes et al, 2002;Huber et al, 2003;Andreozzi et al, 2004;Bruchet et al, 2004;Huber et al, 2005;Westerhoff et al, 2005;Xu et al, 2005;Vieno et al, 2006;Simazaki et al, 2008) were refereed to extract reliable data with experimental conditions close to typical operating conditions at water treatment plants in Japan, i.e., initial chlorine dose and contact time.…”

Section: Selection Of Evaluation Criteria and Data Collectionmentioning

confidence: 99%

Monitoring Priority of Residual Pharmaceuticals in Water Sources and Drinking Water in Japan

Simazaki

Hiramatsu²,

Fujiwara³

et al. 2014

J. of Wat. ^|^ Envir. Tech.

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Monitoring priority of a wide variety of pharmaceuticals was determined in regard to the probability of occurrence in water sources and drinking water in Japan. One hundred and twenty six pharmaceuticals currently in Japanese market, i.e. prescription drugs, over-the-counter (OTC) drugs, veterinary drugs and antibiotics for aquaculture were chosen by literature review and database search. Six evaluation criteria were selected for the determination of monitoring priority of the pharmaceuticals based on occurrence in water sources and drinking water, as well as possible impacts on human health, i.e. annual production, human urinary excretion, octanol-water partition coefficient (log Kow), biodegradation, removal capability by conventional water treatments, and minimum daily therapeutic dose (or acceptable daily intake (ADI) if available). Methodology of the prioritization adopted in this study were found to be appropriate because all of the six pharmaceuticals (i.e., amantadine, carbamazepine, epinastine, ibuprofen, iopamidol and oseltamivir acid) detected in finished drinking water in Japan appeared among the top 25 on the monitoring priority list. Further field investigations on the high-priority pharmaceuticals should be considered to elucidate the overall picture of residual pharmaceuticals in water environment and drinking water, and their potential implications for human health.

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Analysis of drugs and personal care products in French source and drinking waters: the analytical challenge and examples of application

Cited by 60 publications

References 4 publications

A Preliminary Study on the Occurrence of Pharmaceutically Active Compounds in the River Basins and Their Removal in Two Conventional Drinking Water Treatment Plants in Chongqing, China

A Preliminary Study on the Occurrence of Pharmaceutically Active Compounds in the River Basins and Their Removal in Two Conventional Drinking Water Treatment Plants in Chongqing, China

Human dermal exposure to galaxolide from personal care products

Monitoring Priority of Residual Pharmaceuticals in Water Sources and Drinking Water in Japan

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