Analysis of durability and replacement of vocal prostheses in total laryngectomy patients at a head and neck surgery referral center

Pires, Rafael Cardoso; Gama, Ricardo Ribeiro; da Silveira Júnior, Paulo Sérgio; Teixeira, Fernanda Marsico; Santos, Carlos Roberto; de Castro Capuzzo, Renato

doi:10.1007/s00405-023-08180-w

Eur Arch Otorhinolaryngol

2023

DOI: 10.1007/s00405-023-08180-w

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Analysis of durability and replacement of vocal prostheses in total laryngectomy patients at a head and neck surgery referral center

Rafael Cardoso Pires,

Ricardo Ribeiro Gama,

Paulo Sérgio da Silveira Júnior

et al.

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2024

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Oncological and functional outcome after laryngectomy for laryngeal and hypopharyngeal cancer: a population-based analysis in Germany from 2001 to 2020

Kouka,

Beckmann,

Bitter

et al. 2024

Sci Rep

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Prognostic factors for overall survival (OS), percutaneous endoscopic gastrostomy (PEG) dependency, and long-term speech rehabilitation via voice prosthesis (VP) after laryngectomy for laryngeal or hypopharyngeal cancer were investigated in a retrospective population-based study in Thuringia, Germany. A total of 617 patients (68.7% larynx; hypopharynx; 31.3%; 93.7% men; median age 62 years; 66.0% stage IV) from 2001 to 2020 were included. Kaplan–Meier and Cox multivariable regression analyses were performed. 23.7% of patients received a PEG. 74.7% received a VP. Median OS was 131 months. Independent factors for lower OS were stage IV (compared to stage II; hazard ratio [HR] = 3.455; confidence interval [CI] 1.395–8.556) and laryngectomy for a recurrent disease (HR = 1.550; CI 1.078–2.228). Median time to PEG removal was 7 months. Prior partial surgery before laryngectomy showed a tendency for independent association for later PEG removal (HR = 1.959; CI 0.921–4.167). Postoperative aspiration needing treatment was an independent risk factor (HR = 2.679; CI 1.001–7.167) for later definitive VP removal. Laryngectomy continuously plays an important role in a curative daily routine treatment setting of advanced laryngeal or hypopharyngeal cancer in Germany. Long-term dependency on nutrition via PEG is an important issue, whereas use of VP is a stable long-term measure for voice rehabilitation.

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Oncological and functional outcome after laryngectomy for laryngeal and hypopharyngeal cancer: a population-based analysis in Germany from 2001 to 2020

Kouka,

Beckmann,

Bitter

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

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Analysis of durability and replacement of vocal prostheses in total laryngectomy patients at a head and neck surgery referral center

Cited by 1 publication

References 33 publications

Oncological and functional outcome after laryngectomy for laryngeal and hypopharyngeal cancer: a population-based analysis in Germany from 2001 to 2020

Oncological and functional outcome after laryngectomy for laryngeal and hypopharyngeal cancer: a population-based analysis in Germany from 2001 to 2020

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