The assessment of the structural integrity of nuclear vessels is based on a series of procedures developed in the 1970s and 1980s. On one hand, curves that, according to the American Society of Mechanical Engineers code, describe the relationship between steel toughness and temperature in the ductile-to-brittle transition region, based on the reference temperature concept RT NDT , were adopted in 1972. On the other hand, the material embrittlement derived from the exposure of steel to neutron irradiation is determined through the model included in "Regulatory Guide 1.99 Rev. 2," published in 1988. Since then, there have been enormous advances in this field. For example, the Master Curve, based on the reference temperature T 0 , describes the relationship between toughness and temperature in the transition zone more realistically and with much more robust microstructural and mechanical foundations and uses the elastic-plastic fracture toughness K Jc . Moreover, improved models have been developed to estimate the embrittlement of steel subjected to neutron irradiation, such as ASTM E900, Standard Guide for Predicting Radiation-Induced Transition Temperature Shift in Reactor Vessel Materials. This study is aimed at comparing the results obtained using traditional procedures to the improved alternatives developed later. For this purpose, the behavior of the steel of a nuclear vessel that is currently under construction has been experimentally characterized through RT NDT and T 0 parameters. In addition, the material embrittlement has been quantified using "Regulatory Guide 1.99 Rev. 2" and ASTM E900. These experimental results 4 Equipos Nucleares, S.A., S.M.E. Av.