Analysis of Dynamic Geometric Configuration of the Aortic Channel from the Perspective of Tornado-Like Flow Organization of Blood Flow

Zhorzholiani, Sh. T.; Mironov, A. A.; Талыгин, Е. А.; Tsyganokov, Yu. M.; Agafonov, A. M.; Кикнадзе, Г. И.; Gorodkov, A. Yu.; Bokeriya, L. A.

doi:10.1007/s10517-018-4023-z

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Elastometric and angiographic measurements showed that this regularity is obeyed at normal pressure in the aortic lumen. Pressure rise to values > 150 mm Hg causes a distortion of this regularity [ 40 ].…”

Section: Experimental Results Showing That the Blood Flow Structure Corresponds To Swirling Irrotational Flowsmentioning

confidence: 99%

The Hydrodynamics of a Swirling Blood Flow in the Left Heart and Aorta

et al. 2021

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This paper proposes a new approach to the quantitative analysis of the hydrodynamic structure of a blood flow in the flow channel running from the left atrium to the end of the aorta. This approach is based on the concept of the structural organization of tornado-like swirling jets in channels with a given geometric configuration. Considering the large amount of experimental data in our possession, it was shown that along the entire length of the flow channel, conditions exist for the generation and maintenance of a swirling structure of the jet throughout the entire cardiac cycle. This study has given rise to a new direction in research in fundamental physiology and medicine, which is of great practical importance for diagnosing and treating circulatory disorders accompanied by changes in the geometric configuration and biomechanical characteristics of the heart and great vessels.

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Section: Experimental Results Showing That the Blood Flow Structure Corresponds To Swirling Irrotational Flowsmentioning

confidence: 99%

The Hydrodynamics of a Swirling Blood Flow in the Left Heart and Aorta

et al. 2021

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“…In previously published works, it was proven that the blood flow in the heart and main arteries has a spiral nature, which is described by exact solutions of non-stationary hydrodynamic equations for the class of tornado-like viscous fluid flows [ 10 ]. The non-stationary regime of blood flow requires that, in order to maintain the necessary geometric configuration of the flow channel, its boundaries should be sufficiently flexible, which is possible only for radially elastic walls.…”

Section: Introductionmentioning

confidence: 99%

Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta

Gorodkov

Tsygankov

Шепелев

et al. 2022

JFB

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A significant drawback of the rigid synthetic vascular prostheses used in the clinic is the mechanical mismatch between the implant and the prosthetic vessel. When placing prostheses with radial elasticity, in which this deficiency is compensated, the integration of the graft occurs more favorably, so that signs of cell differentiation appear in the prosthesis capsule, which contributes to the restoration of vascular tone and the possibility of vasomotor reactions. Aortic prostheses fabricated by electrospinning from a blend of copolymers of vinylidene fluoride with hexafluoropropylene (VDF/HFP) had a biomechanical behavior comparable to the native aorta. In the present study, to ensure mechanical stability in the conditions of a living organism, the fabricated blood vessel prostheses (BVP) were cross-linked with γ-radiation. An optimal absorbed dose of 0.3 MGy was determined. The obtained samples were implanted into the infrarenal aorta of laboratory animals—Landrace pigs. Histological studies have shown that the connective capsule that forms around the prosthesis has signs of high tissue organization. This is evidenced by the cells of the fibroblast series located in layers oriented along and across the prosthesis, similar to the orientation of cells in a biological arterial vessel.

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