Analysis of early-onset bloodstream infection due to Escherichia coli infection in premature babies

Chen, I‐Lun; Huang, Hsin‐Chun; Wu, Chih-Te; Ou‐Yang, Mei‐Chen; Chung, Mei‐Ing; Chen, Chih‐Cheng; Suen, Jau‐Ling; Hung, Chih‐Hsing

doi:10.1097/md.0000000000007748

Cited by 4 publications

(4 citation statements)

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“…Full-text screening excluded an additional 5 articles, providing an evidence base of 87 studies (figure 1). 10–96 The 87 studies included in the qualitative analysis were conducted between 1991 and 2017 in 25 countries, mainly in South Korea (14 studies), Thailand (7), USA (7), Taiwan (7) and Spain (7). Sixty (68.9%) studies were performed in HICs, 26 (29.9%) in LMICs and 1 included both HICs and LMICs 56.…”

Section: Resultsmentioning

confidence: 99%

Variation of effect estimates in the analysis of mortality and length of hospital stay in patients with infections caused by bacteria-producing extended-spectrum beta-lactamases: a systematic review and meta-analysis

Shamsrizi

Gladstone

Carrara³

et al. 2020

BMJ Open

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ObjectiveTo assess the variation of effect estimates in the analysis of mortality and length of stay (LOS) in patients with infections caused by extended-spectrum beta-lactamase (ESBL)-producingEnterobacteriaceae.DesignSystematic review and meta-analysisMethodsLiterature search for clinical studies from 1 January 1960 to 1 October 2018 was conducted in PubMed. Primary outcomes were risk ratios (RRs) of all-cause and attributable mortality and weighted mean differences (WMDs) in LOS in patients with bloodstream infections (BSIs) and non-invasive infections. Any change in the effect estimates was assessed by grouping studies according to design, setting, economy-based country classification, reporting period, microbiological aetiology, infection type and adjustment for appropriateness of empirical treatment. The impact of ESBL production was calculated using random-effect meta-analysis and heterogeneity was evaluated by I2statistics and metaregression.ResultsEighty-four studies including 22 030 patients and 149 outcome measures were included in the meta-analysis. Most studies were retrospective cohorts from high-income countries, providing unadjusted estimates. ESBL production in patients with BSIs (56 studies) increased the RR for all-cause mortality by a factor of 1.70 (95% CI 1.52 to 1.90; p<0.001), attributable mortality (16 studies) by 1.75 (95% CI 1.448 to 2.108; p<0.001) and WMD in the intensive care unit by 3.07 days (95% CI 1.61 to 4.54; p<0.001). WMD in hospital LOS was significantly higher in BSIs (4.41 days; 95% CI 3.37 to 5.46; p<0.001) and non-invasive (2.19 days; 95% CI 1.56 to 2.81; p<0.001). Subgroup analyses showed variation of estimates by study design, population, strain and assessment of appropriateness of empiric treatment. High heterogeneity was observed in all analyses.ConclusionsCurrent evidence of the clinical burden of infections caused by ESBL-producing bacteria is highly heterogeneous and based mainly on unadjusted estimates derived from retrospective studies. Despite these limitations, ESBL production in strains causing BSIs seems associated with higher all-cause and attributable mortality and longer hospitalisation.

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Section: Resultsmentioning

confidence: 99%

Variation of effect estimates in the analysis of mortality and length of hospital stay in patients with infections caused by bacteria-producing extended-spectrum beta-lactamases: a systematic review and meta-analysis

Shamsrizi

Gladstone

Carrara³

et al. 2020

BMJ Open

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“…Among the 404 clinical specimens from patients with community-onset E. coli bacteremia in a medical center in southern Taiwan, Hsieh et al identified only 19 (4.7%) isolates were ESBL producers ( Hsieh et al, 2010 ). For premature babies with E. coli bacteremia, a small study including 27 cases showed five (18.5%) isolates were ESBL producers ( Chen I. L. et al, 2017 ). Additionally, this study found that the level of serum alanine aminotransferase was significantly lower in the ESBL-producing E. coli group than that in the non-ESBL-producing E. coli group ( Chen I. L. et al, 2017 ).…”

Section: Esbl Prevalence Of Specific Pathogensmentioning

confidence: 99%

“…For premature babies with E. coli bacteremia, a small study including 27 cases showed five (18.5%) isolates were ESBL producers ( Chen I. L. et al, 2017 ). Additionally, this study found that the level of serum alanine aminotransferase was significantly lower in the ESBL-producing E. coli group than that in the non-ESBL-producing E. coli group ( Chen I. L. et al, 2017 ).…”

Section: Esbl Prevalence Of Specific Pathogensmentioning

confidence: 99%

Epidemiology of extended-spectrum β-lactamases in Enterobacterales in Taiwan for over two decades

Chao

Lai

2023

Front. Microbiol.

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The emergence of antimicrobial resistance among microorganisms is a serious public health concern, and extended-spectrum β-lactamases (ESBL)-producing Enterobacterales is one of the major concerns among antibiotic-resistant bacteria. Although the prevalence of ESBL in Enterobacterales has been increasing with time, the prevalence of ESBL could differ according to the species, hospital allocation, sources of infections, nosocomial or community acquisitions, and geographic regions. Therefore, we conducted a comprehensive review of the epidemiology of ESBL-producing Enterobacterales in Taiwan. Overall, the rates of ESBL producers are higher in northern regions than in other parts of Taiwan. In addition, the genotypes of ESBL vary according to different Enterobacterales. SHV-type ESBLs (SHV-5 and SHV-12) were the major types of Enterobacter cloacae complex, but Serratia marcescens, Proteus mirabilis, Escherichia coli, and Klebsiella pneumoniae were more likely to possess CTX-M-type ESBLs (CTX-M-3 and CTX-M-14). Moreover, a clonal sequence type of O25b-ST131 has been emerging among urinary or bloodstream E. coli isolates in the community in Taiwan, and this clone was potentially associated with virulence, ESBL (CTX-M-15) production, ciprofloxacin resistance, and mortality. Finally, the evolution of the genetic traits of the ESBL-producing Enterobacterales isolates helps us confirm the interhospital and intrahospital clonal dissemination in several regions of Taiwan. In conclusion, continuous surveillance in the investigation of ESBL production among Enterobacterales is needed to establish its long-term epidemiology.

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“…The prevalence and resistance of bacteria have increased over time due to the use of antibiotics in different countries. As a result, continuous epidemiological monitoring along with frequent local adjustment of susceptibility patterns to antimicrobial agents is essential to establish a rational treatment approach [10] . Objectives: The aim of this study was to evaluate the incidence of sepsis caused by E. coli and its antibiotic resistance pattern as well as to assess the potential risk factors in neonates and maternal characteristics in Shiraz.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Antibiotic Susceptibility of Escherichia coli Isolated from Early-Onset Sepsis in Shiraz, Iran

Rezaei

Javanmardi

Pirbonyeh

et al. 2021

IEM

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Background: Neonatal sepsis is a clinical syndrome in neonates, which is an uncommon but significant cause of morbidity and mortality in infants. The aim of this study was to evaluate the incidence of sepsis caused by Escherichia coli and its antibiotic resistance pattern as well as to assess the potential risk factors in neonates and maternal characteristics in Shiraz.Material & Method: This retrospective study was performed on infants with sepsis in the first three days of life during February 2019 to March 2021. Patients' information was obtained using their hospital records and a questionnaire. All statistical analyses were conducted using SPSS software Ver. 18.0. A p-value <.05 was considered as statistically significant Findings: During this study, a total of 250 positive blood cultures were reported for infants less than 3 days old. Of these, 21(8.4%) E. coli strains were isolated from 14 preterm and 7 term neonates. In all patients, the most effective antibiotic was meropenem, and the highest resistance was observed to cefoxitin. Conclusion:Base on the present study results, E. coli is the most prevalent Gram-negative bacterium isolated in Shiraz. Premature birth and very low weight are the most important risk factors for developing early-onset sepsis.

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Analysis of early-onset bloodstream infection due to Escherichia coli infection in premature babies

Cited by 4 publications

References 21 publications

Variation of effect estimates in the analysis of mortality and length of hospital stay in patients with infections caused by bacteria-producing extended-spectrum beta-lactamases: a systematic review and meta-analysis

Variation of effect estimates in the analysis of mortality and length of hospital stay in patients with infections caused by bacteria-producing extended-spectrum beta-lactamases: a systematic review and meta-analysis

Epidemiology of extended-spectrum β-lactamases in Enterobacterales in Taiwan for over two decades

Prevalence and Antibiotic Susceptibility of Escherichia coli Isolated from Early-Onset Sepsis in Shiraz, Iran

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