Abstract. Alzheimer Disease (AD) early detection is considered of high importance for improving the quality of life of patients and their families. Amongst all the different approaches for AD detection, significant work has been focused on emotion analysis through facial expressions, body language or speech. Many studies also use the electroencephalogram in order to capture emotions that patients cannot physically express. Our work introduces an emotion recognition approach using facial expression and EEG signal analysis. A novel dataset was created specifically to remark the autobiographical memory deficits of AD patients. This work uses novel EEG features based on quaternions, facial landmarks and the combination of them. Their performance was evaluated in a comparative study with a state of the art methods that demonstrates the proposed approach.