Analysis of ergotoxine alkaloids in ergot strains by the NMR method

Komarova, E. L.; Шейченко, В. И.; Shain, S. S.

doi:10.1007/bf02219533

Cited by 3 publications

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“…If work on the ergoalkaloid composition determination and identification is necessary, the samples of sclerotium selected upon a large-scale analysis are subjected to field tests in order to obtain intermediate samples with an average weight of not less than 100 g. The exhaustive study of alkaloid composition in the new and experimental ergot strains is performed using HPLC and NMR [14], electrophoresis [15], and other analytical techniques.…”

Section: Resultsmentioning

confidence: 99%

Selected ergot strains identified by alkaloid composition of an individual sclerotium

Komarova

Shain

1998

Pharm Chem J

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Section: Resultsmentioning

confidence: 99%

Selected ergot strains identified by alkaloid composition of an individual sclerotium

Komarova

Shain

1998

Pharm Chem J

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“…It was reported that epimerisation is promoted under acidic and alkaline conditions, which are often used during e.g. extraction of grain samples (Komarova & Tolkachev, 2001; Krska et al., 2008). The stability of EA standards in solvent was assessed by Hafner et al.…”

Section: Introductionmentioning

confidence: 99%

Risks for animal health related to the presence of ergot alkaloids in feed

Schrenk,

Bignami,

Bodin

et al. 2024

EFS2

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The European Commission requested EFSA to provide an update of the 2012 Scientific Opinion of the Panel on Contaminants in the Food Chain (CONTAM) on the risks for animal health related to the presence of ergot alkaloids (EAs) in feed. EAs are produced by several fungi of the Claviceps and Epichloë genera. This Opinion focussed on the 14 EAs produced by C. purpurea (ergocristine, ergotamine, ergocornine, α‐ and β‐ergocryptine, ergometrine, ergosine and their corresponding ‘inine’ epimers). Effects observed with EAs from C. africana (mainly dihydroergosine) and Epichloë (ergovaline/−inine) were also evaluated. There is limited information on toxicokinetics in food and non‐food producing animals. However, transfer from feed to food of animal origin is negligible. The major effects of EAs are related to vasoconstriction and are exaggerated during extreme temperatures. In addition, EAs cause a decrease in prolactin, resulting in a reduced milk production. Based on the sum of the EAs, the Panel considered the following as Reference Points (RPs) in complete feed for adverse animal health effects: for pigs and piglets 0.6 mg/kg, for chickens for fattening and hens 2.1 and 3.7 mg/kg, respectively, for ducks 0.2 mg/kg, bovines 0.1 mg/kg and sheep 0.3 mg/kg. A total of 19,023 analytical results on EAs (only from C. purpurea) in feed materials and compound feeds were available for the exposure assessment (1580 samples). Dietary exposure was assessed using two feeding scenarios (model diets and compound feeds). Risk characterisation was done for the animals for which an RP could be identified. The CONTAM Panel considers that, based on exposure from model diets, the presence of EAs in feed raises a health concern in piglets, pigs for fattening, sows and bovines, while for chickens for fattening, laying hens, ducks, ovines and caprines, the health concern related to EAs in feed is low.

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“…Lysergic acid diethylamide is especially interesting because, as an alkaloid from the ergoline family, it is known for its "altered thinking capacity, closed and open eyes visuals, synaesthesia and sense of time distortion." 376 These responses are purportedly similar to the result of Gurdjieff-like inductions, although in this thesis only Ouspensky's 1917 experience in Essentuki has been offered as an example, whereby descriptions have registered a hypnotic trance-like experience and Ouspensky reports he received an 'intensive psycho-somatic experimentation. Lysergic acid diethylamide has been extensively studied by psychiatrists and is used medicinally for its vasoconstrictor capability, and is primarily "used in the treatment of hypertension."…”

Section: Dr Peter Fenwick 1935-presentmentioning

confidence: 82%

Self-remembering: Georges Ivanovitch Gurdjieff (1870-1949) & his legacy

Nicholls-Parker¹

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<p>The subject of this thesis is the spiritual practices taught by Gurdjieff (1870-1949) and the legacy of these teachings in the major spiritual groups that have aspired to follow his path. I argue that at the core of these spiritual techniques are the practices that Gurdjieff referred to as “self-remembering” and “transition” and that by an analysis of these it is possible to articulate Gurdjieff’s spiritual system in a novel fashion. This articulation is then utilized to explore the different ways in which his system was developed by his disciples. The more recent studies of spirituality and spiritual techniques allow us to critically reconsider Gurdjieff and his legacy in a systemic and academic fashion. The thesis concludes that while Gurdjieff was a man and teacher of his time many of the themes of his teachings continue to resonate in contemporary spiritual movements and that his influence has been wider than is often acknowledged, and that at the centre of this legacy are his spiritual techniques. Gurdjieff used storytelling to advance an in-depth understanding of his teaching to his principal followers and it is through an evaluation of this investment that the promotion of self-awareness is seen as pivotal and central to any evaluation of the spiritual legacy. The way to distinguish Gurdjieff’s teaching from other of his principal followers, now 100 years on, is evident when contemporary literature can provide a valuable and insightful means to differentiate influence. The key contribution offered in the name of contemplative neuroscience in this thesis reveals that Gurdjieff taught by employing a narrative self-focus, while his principal followers taught by employing a self-reverential devotional focus. This sets the benchmark of the legacy up anew as reflecting at least two different theological approaches: self-focused or self-reverential. My critical analysis of Gurdjieff’s techniques will differ from a number of academic appraisals in that essentially hagiography is offered as a replacement for biography, and in this way with the assistance of phenomenology the legacy can be explained in a more true and reasonable fashion. This is because the lesser weight on biography allows the phenomenological perspectives to assist the teachings arrival at the ethereal state crystallization, revealing Gurdjieff’s personal agenda and indicating his means of delivery.</p>

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Analysis of ergotoxine alkaloids in ergot strains by the NMR method

Cited by 3 publications

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Selected ergot strains identified by alkaloid composition of an individual sclerotium

Selected ergot strains identified by alkaloid composition of an individual sclerotium

Risks for animal health related to the presence of ergot alkaloids in feed

Self-remembering: Georges Ivanovitch Gurdjieff (1870-1949) & his legacy

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