2022
DOI: 10.3390/cancers14133216
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Analysis of Exosomal Cargo Provides Accurate Clinical, Histologic and Mutational Information in Non-Small Cell Lung Cancer

Abstract: Lung cancer is a malignant disease with high mortality and poor prognosis, frequently diagnosed at advanced stages. Nowadays, immense progress in treatment has been achieved. However, the present scenario continues to be critical, and a full comprehension of tumor progression mechanisms is required, with exosomes being potentially relevant players. Exosomes are membranous vesicles that contain biological information, which can be transported cell-to-cell and modulate relevant processes in the hallmarks of canc… Show more

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Cited by 8 publications
(7 citation statements)
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“…EVs are an important part of TME acting as effective signaling molecules between cancer cells and the surrounding cells [ 47 ]. We had previously performed an exhaustive characterization of NSCLC EVs revealing that EVs cargo can reflect the molecular signatures and their capacity to be used as a tool for diagnosis and prognosis [ 48 ]. In view of potential role of secreted Gal‐3 as an immunomodulator molecule, we analyzed EVs‐associated Gal‐3 in our cohort of cell cultures.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…EVs are an important part of TME acting as effective signaling molecules between cancer cells and the surrounding cells [ 47 ]. We had previously performed an exhaustive characterization of NSCLC EVs revealing that EVs cargo can reflect the molecular signatures and their capacity to be used as a tool for diagnosis and prognosis [ 48 ]. In view of potential role of secreted Gal‐3 as an immunomodulator molecule, we analyzed EVs‐associated Gal‐3 in our cohort of cell cultures.…”
Section: Discussionmentioning
confidence: 99%
“…Despite this, some limitations such as partial clinical outcome information which might lead to some uncertainties in the results. Nevertheless, TCGA database is public, provide massive information and allows carry out in silico analysis such performed previously in our laboratory [ 22 , 48 ].…”
Section: Discussionmentioning
confidence: 99%
“…Although, the cargo contained within these sEVs are a variety including proteins, lipids and nucleic acids (Zhang et al, 2019b ). The miRNAs, a class of small non-coding RNAs, have emerged as the most studied cargo owing to their diverse function and multiple targets (Duréndez-Sáez et al, 2022 ). The miRNAs are released by cells in extracellular space encapsulated within the small EVs or without encapsulation in a vesicle-free form (Lee et al, 2019 ).…”
Section: Discussionmentioning
confidence: 99%
“…Regarding ctDNA, few studies have been conducted to date, but it appears that high levels of ctDNA may be indicative of a worse prognosis (Abbosh et al, 2017). The potential of EVs to be a source of biomarkers for prognosis has also been proposed (Duréndez-Sáez et al, 2022).…”
Section: The Status In Early Stagesmentioning
confidence: 99%
“…These EVs play a vital role in the TME by contributing as potent signaling molecules in the communication between cancer cells and neighboring cells (Dang et al, 2016). In our previous laboratory work, we conducted a comprehensive characterization on NSCLC EVs, revealing that the cargo within EVs can reflect molecular signatures and serve as a valuable tool for both diagnosis and prognosis (Duréndez-Sáez et al, 2022).…”
Section: Vesiclesmentioning
confidence: 99%