Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

Numata, Shigeki; Akamatsu, Hirohiko; Akaza, Narifumi; Yagami, Akiko; Nakata, Satoshi; Matsunaga, Kayoko

doi:10.1159/000356777

Cited by 29 publications

(30 citation statements)

References 19 publications

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“…Before treatment, the bacterial communities in all sampling locations were similar in acne patients and healthy controls, including Propionibacterium , Staphylococcus , Corynebacterium , Streptococcus and Micrococcus as the dominant genera. Thus, our results are in line with those of several studies based on culturing and sequencing, showing that the skin microbiome is similar in the sebaceous‐rich face and back areas of individuals with healthy skin and untreated acne patients . In a study where nose follicular casts were analysed using 16S rRNA amplicon sequencing, no difference was detected between acne patients and healthy controls in the relative abundance of P. acnes , and the other common bacteria were Staphylococcus epidermidis, Propionibacterium humerusii and Propionibacterium granulosum .…”

Section: Discussionsupporting

confidence: 91%

Isotretinoin and lymecycline treatments modify the skin microbiota in acne

Kelhälä

Aho

Fyhrquist

et al. 2017

Experimental Dermatology

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Oral retinoids and tetracyclines have a major role in acne treatment. Here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16S ribosomal RNA (16S rRNA) gene amplicon sequencing. Propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. Five taxa, including a Streptococcus taxon, differed significantly between the cheek samples of healthy controls and acne patients, and acne severity was positively correlated with the abundance of Propionibacterium. Both treatments reduced clinical acne grades and the abundance of Propionibacterium, while the abundance of several other taxa was significantly higher in treated cheek samples compared with untreated ones. Less variation was observed in back samples and none in armpit samples. There were no differences in alpha diversity between control and acne patients in any of the sampled skin areas, but the diversity of the microbiota on the cheek and the back was significantly increased after acne treatments. This study provides insight into the skin microbiota in acne and how it is modulated by systemic acne treatment.

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Section: Discussionsupporting

confidence: 91%

Isotretinoin and lymecycline treatments modify the skin microbiota in acne

Kelhälä

Aho

Fyhrquist

et al. 2017

Experimental Dermatology

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“…Malassezia spp. have been associated with a wide range of other superficial diseases, including onycomycosis, confluent and reticulated papillomatosis, and acne . However, the evidence linking Malassezia spp.…”

Section: Skin Diseases Associated With Malassezia Sppmentioning

confidence: 99%

Malassezia species in healthy skin and in dermatological conditions

Prohić¹,

Sadikovic²,

et al. 2015

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The genus Malassezia comprises lipophilic species, the natural habitat of which is the skin of humans and other warm-blooded animals. However, these species have been associated with a diversity of dermatological disorders and even systemic infections. Pityriasis versicolor is the only cutaneous disease etiologically connected to Malassezia yeasts. In the other dermatoses, such as Malassezia folliculitis, seborrheic dermatitis, atopic dermatitis, and psoriasis, these yeasts have been suggested to play pathogenic roles either as direct agents of infection or as trigger factors because there is no evidence that the organisms invade the skin. Malassezia yeasts have been classified into at least 14 species, of which eight have been isolated from human skin, including Malassezia furfur, Malassezia pachydermatis, Malassezia sympodialis, Malassezia slooffiae, Malassezia globosa, Malassezia obtusa, Malassezia restricta, Malassezia dermatis, Malassezia japonica, and Malassezia yamatoensis. Distributions of Malassezia species in the healthy body and in skin diseases have been investigated using culture-based and molecular techniques, and variable results have been reported from different geographical regions. This article reviews and discusses the latest available data on the pathogenicity of Malassezia spp., their distributions in dermatological conditions and in healthy skin, discrepancies in the two methods of identification, and the susceptibility of Malassezia spp. to antifungals.

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“…The human skin is colonized by a wide variety of microbes such as bacteria, fungi and viruses. The bacteria on the skin can be divided into resident and temporary bacteria; traditional culture‐based methods show that Cutibacterium and Staphylococcus are the most common resident skin bacteria, while Gram‐negative bacteria are regarded as temporary bacteria with limited distribution on the skin . Culture‐independent technologies have revealed close relationships between the skin microbiome and chronic inflammatory dermatoses, such as atopic dermatitis, psoriasis and acne vulgaris (acne) .…”

Section: Introductionmentioning

confidence: 99%

Skin microbiome differences relate to the grade of acne vulgaris

You

Yuan

et al. 2019

The Journal of Dermatology

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The skin microbiome plays important roles in the pathogenesis and development of acne. We aimed to investigate the facial skin microbiome of acne and microbiome differences related to different grades of acne. Skin swabs from nine healthy controls and 67 acne patients were collected, and the skin microbiomes were analyzed using 16S rRNA gene sequencing. Compared with healthy controls, acne patients harbored significantly altered skin microbiomes. The skin microbiomes of patients with grade 1–3 acne were similar, but patients with grade 4 acne showed a significantly different skin microbiome compared with grade 1–3 acne, including increased alpha diversity and increased proportions of four Gram‐negative bacteria (Faecalibacterium, Klebsiella, Odoribacter and Bacteroides). In conclusion, acne patients harbored an altered skin microbiome, and more significant dysbiosis was found in patients with grade 4 acne (severe acne). Our findings may provide evidence for the pathogenic mechanisms of acne and microbial‐based strategies to avoid and treat acne, especially grade 4 acne.

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Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

Cited by 29 publications

References 19 publications

Isotretinoin and lymecycline treatments modify the skin microbiota in acne

Isotretinoin and lymecycline treatments modify the skin microbiota in acne

Malassezia species in healthy skin and in dermatological conditions

Skin microbiome differences relate to the grade of acne vulgaris

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