Montiel-company the reason of the biological stability loss of mini-implants is still a matter of discussion between dentistry professionals. the main objective of this systematic literature review and meta-analysis was to analyze the risk factors that prejudice this loss. A search was made in the electronic databases pubmed, Scopus, embase and cochrane, in addition a manual search was made too in Grey Literature (opengrey). no limits were set on the year of publication or language. the inclusion criteria were: studies in humans treated with fixed appliances with mini-implants, where the risk factors for secondary stability were evaluated for a minimum of 8 weeks. After eliminating duplicate studies and assessing which ones achieve the inclusion criteria, a total of 26 studies were selected for the qualitative synthesis, 18 of them were included in the quantitative synthesis. Common risk variables were compared in all of them. Analyzing the forest and funnel plots, statistically significant differences were obtained only for location, the upper maxilla having lower risk than the mandible with an odds ratio of 0.56 and confidence interval of 0.39 to 0.80. Prospective studies under controlled conditions should be required in order to obtain a correct assessment of the variables analyzed. The use of mini-implants to provide anchorage for force application has simplified and improved the efficacy of many orthodontic treatments, reducing unwanted movements of other teeth, especially in adult patients. For this reason, anchorage in bone is becoming a much more widely used technique 1. Mini-implants are made of titanium or stainless steel, their structure has three different parts: the top one (supra-gingival, which allows the anchor), the medium area or neck, and the thread, which is inserted inside the bone and provides mechanic anchor. Moreover, the most common types of mini-implants are: Mini Implant System (dbOrthodontics), Vector Temporary Anchorage System (Omco) and the Abso Anchor System (Dentos). All of them are available in different lengths (6-12 mm) and diameters (1-2 mm) 2. Mini-implants or TADs (Temporary Anchorage Devices) 2 have been used mainly as an auxiliary fixing method but more recently have been adopted for additional functions such as: mid-line or inclined plane alignment, space opening, or molar intrusion or extrusion 3. The increasing use of mini-implants is justified by its multiple advantages, the simplicity of the surgical technique, and low cost. Moreover, it is well accepted by patients and achieves success rates of 80-90% 4. While failure may be avoided by establishing the right therapeutic protocols, the fact that a percentage of mini-implants fail should not be overlooked. Stability refers to the resistance to reactive forces, offered by teeth or other oral or extraoral structures, that would lead to unwanted movements 5. In the case of mini-implants, two types of stability can be distinguished: primary and secondary. Primary stability is mechanical and is achieved by the mini-implant c...