Analysis of factors related to the occurrence of chronic disseminated candidiasis in patients with acute leukemia in a non-bone marrow transplant setting

Sallah, Sabah; Wan, Jim Y.; Nguyen, Nam P.; Vos, Paul; Sigounas, George

doi:10.1002/1097-0142(20010915)92:6<1349::aid-cncr1457>3.0.co;2-e

Cited by 45 publications

(37 citation statements)

References 21 publications

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“…Broad-spectrum antibiotic use has been associated with increases in Candida colonization and the risk of disseminated candidiasis (152,200). Similar to burns and percutaneous catheter placement, which disrupt skin barriers, chemotherapy and radiation induce the disruption of gut mucosal barriers and increase the risk of invasive Candida infections (270,291). Neutropenia is associated with an increased risk of invasive candidiasis and increased mortality due to invasive candidiasis (234).…”

Section: Health Care-associated Fungal Infectionsmentioning

confidence: 99%

Hospital Epidemiology and Infection Control in Acute-Care Settings

2011

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SUMMARY Health care-associated infections (HAIs) have become more common as medical care has grown more complex and patients have become more complicated. HAIs are associated with significant morbidity, mortality, and cost. Growing rates of HAIs alongside evidence suggesting that active surveillance and infection control practices can prevent HAIs led to the development of hospital epidemiology and infection control programs. The role for infection control programs has grown and continues to grow as rates of antimicrobial resistance rise and HAIs lead to increasing risks to patients and expanding health care costs. In this review, we summarize the history of the development of hospital epidemiology and infection control, common HAIs and the pathogens causing them, and the structure and role of a hospital epidemiology and infection control program.

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Section: Health Care-associated Fungal Infectionsmentioning

confidence: 99%

Hospital Epidemiology and Infection Control in Acute-Care Settings

2011

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“…2 The use of broad-spectrum antibiotics also is a wellknown risk factor for invasive fungal infection in hematology patients. Chronic disseminated candidiasis in patients with acute leukemia and/or bone marrow transplantation has been independently associated with the use of quinolone antibiotics in particular, 3 and a recent observational study showed that 92% of patients with candidemia had received broad-spectrum antibiotics. 4 Important risk factors for C. difficile-associated disease in hematology patients include the number and duration of antibiotics received, with particular risk attached to certain classes, such as cephalosporins.…”

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confidence: 99%

The role of antibiotic stewardship in limiting antibacterial resistance among hematology patients

Gyssens¹,

Kern

Livermore

2013

Haematologica

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“…Depending on host immunity, infection by this organism can be either superficial or hematogenously disseminated, resulting in life-threatening systemic candidiasis (19,24,27,28,38,44,45). C. albicans undergoes a reversible switch between yeast, pseudohyphal, and hyphal growth in response to various stimuli (36,40).…”

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confidence: 99%

Candida albicans Csy1p Is a Nutrient Sensor Important for Activation of Amino Acid Uptake and Hyphal Morphogenesis

2004

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Candida albicans is an important human pathogen that displays a remarkable ability to detect changes in its environment and to respond appropriately by changing its cell morphology and physiology. Serum-and amino acid-based media are known to induce filamentous growth in this organism. However, the mechanism by which amino acids induce filamentation is not yet known. Here, we describe the identification and characterization of the primary amino acid sensor of C. albicans, Csy1. We show that Csy1p plays an important role in amino acid sensing and filamentation. Loss of Csy1p results in a lack of amino acid-mediated activation of amino acid transport and a lack of induction of transcription of specific amino acid permease genes. Furthermore, a csy1⌬/csy1⌬ strain, lacking Csy1p, is defective in filamentation and displays altered colony morphology in serum-and amino acid-based media. These data provide the first evidence that C. albicans utilizes the amino acid sensor Csy1p to probe its environment, coordinate its nutritional requirements, and determine its morphological state.

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Analysis of factors related to the occurrence of chronic disseminated candidiasis in patients with acute leukemia in a non-bone marrow transplant setting

Cited by 45 publications

References 21 publications

Hospital Epidemiology and Infection Control in Acute-Care Settings

Hospital Epidemiology and Infection Control in Acute-Care Settings

The role of antibiotic stewardship in limiting antibacterial resistance among hematology patients

Candida albicans Csy1p Is a Nutrient Sensor Important for Activation of Amino Acid Uptake and Hyphal Morphogenesis

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