Analysis of failures following local treatment of isolated local-regional recurrence of breast cancer

Outcomes of high-dose chemotherapy and autologous stem cell transplant in isolated locally recurrent breast cancer: a multicenter evaluation

“…Complete excision for LRR following mastectomy has been a favorable prognostic factor in several series of patients treated with conventional therapy. 9,11,12,20 Patients with ER positive tumors demonstrated a trend to better OS on univariate analysis, and in the multivariate model, predicted for both improved PFS and OS. This is in concordance with the overall favorable outlook of patients with ER positive disease.…”

“…Analysis of prognostic factors has shown that results appeared to be optimal when, excision of the macroscopic recurrence was complete, and was followed by at least 4500 cGy of involved field RT. 9,11,12,20 Other factors associated with a favorable prognosis included DFI Ͼ2 years and ER positive recurrence; whereas factors associated with a poor prognosis included recurrence in a supraclavicular node, combined chest wall and nodal recurrence, multiple recurrences or largest recurrence Ͼ1 cm. [8][9][10][11][12][13][14][15][16][17][18][19][20] In some series, characteristics of the primary tumor have had prognostic significance.…”

“…9,11,12,20 Other factors associated with a favorable prognosis included DFI Ͼ2 years and ER positive recurrence; whereas factors associated with a poor prognosis included recurrence in a supraclavicular node, combined chest wall and nodal recurrence, multiple recurrences or largest recurrence Ͼ1 cm. [8][9][10][11][12][13][14][15][16][17][18][19][20] In some series, characteristics of the primary tumor have had prognostic significance. 9,[13][14][15][16][17]23,24 These studies were all limited by their design (mostly retrospective or noncontrolled), small patient numbers, variable treatments administered, and/or short follow-up.…”

“…However, in contrast to several series of conventional therapy for LRR and of HDCT for metastatic disease, DFI was not predictive of PFS or OS in our study. [8][9][10][11][12][13][14][15][16][17][18][19][20] The site of recurrence and involvement of supraclavicular nodes did not predict for PFS or OS.…”

“…[1][2][3][4][5][6][7] The early literature, which describes the outcomes of women with LRR following mastectomy, evaluated primarily local therapeutic options including either RT and/or surgical therapy. [8][9][10][11][12][13][14][15][16][17][18][19][20] The 5-year progression-free survival (PFS) and overall survival (OS) in these series ranged between 13-37% and 21-50%, respectively. However, since LRR following mastectomy is usually an initial manifestation of systemic disease, it is logical to combine systemic therapy with local treatment.…”