This paper proposes a new methodology for physics-based aircraft multidisciplinary design optimization (MDO) and sensitivity analysis. The proposed architecture uses signomial programming (SP), a type of difference-of-convex optimization that is solved iteratively as a series of log-convex problems. A requirement of SP is that all constraints and objective functions must have explicit signomial formulas. The SP MDO architecture facilitates the low-cost computation of optimal sensitivities through Lagrange duality. The specific example of commercial aircraft MDO is considered. Using SP, a small-, medium-, and large-scale benchmark problem is solved 16, 39, and 26 times faster, respectively, than Transport Aircraft System Optimization (TASOPT), a comparable and widely used aircraft MDO tool. The SP solution times include computation of all optimal parameter and constraint sensitivities, a feature unique to the presented architecture. The reliability of SP is demonstrated by converging a commercial aircraft MDO problem for a number of different objective functions and evaluating both traditional and nontraditional aircraft configurations. While the presented example is commercial aircraft MDO, the SP MDO architecture is applicable to a range of engineering optimization problems.