Analysis of Fluid in Craniopharyngioma-Related Cysts in Children: Proteins, Lactate and pH

Arefyeva, I A; Semenova, J. B.; Zubairaev, M. S.; Kondrasheva, E. A.; Moshkin, A. V.

doi:10.1007/s007010200077

Cited by 20 publications

(14 citation statements)

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“…Much recent research aims to characterize the cyst fluid to understand the mechanism of formation and to refine treatments able to reduce cyst volume and inhibit the formation of new cysts. Indeed, the formation mechanism of cystic fluid has always been debated: it could be the result of blood-brain barrier impairment [2], but surely an active secretory process takes part in its formation [3,4], or is due to epithelial cells secretion [6,7], rupture of those structures [8,9], oil machinery fluid components of the cyst structures or is secondary to an immune response that produce and spontaneous involution [11]. Spontaneous rupture of craniopharyngioma cysts can be divided into three subtypes: cyst rupture associated with chemical meningitis; cyst rupture with improvement in symptoms related to the craniopharyngioma and not associated with chemical meningitis; and asymptomatic rupture [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…They are the most common non-glial tumors in childhood [2], and originate from the embryonic remains of squamous cells through the hypophyseal-pharyngeal duct [1][2][3]. The pathology of cyst formation, inflammation and immune response have been always questioned [4]. The cystic portion of the CP is filled with secreted fluid, cholesterol crystals, and epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, its presence is associated with a major risk of recurrence, and thus suggesting a proliferative appliance in its genesis and growth, rupture, and inflammatory and immune response. Indeed, the cyst fluid recurs after multiple aspirations and the epithelium of the cyst is the actively proliferating component due to the presence of secretory squamous cells and of zymogen granules [4]. Due to the secretive properties of this epithelium, most part of PC has a cystic portion containing secreted fluid, cholesterol crystals, and epithelial cells [1].…”

Section: Introductionmentioning

confidence: 99%

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Running Head: Craniopharyngioma and Immune Response

TS¹,

SL²,

HC³

2015

J Neurol Neurosci

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Background: Craniopharyngioma is a rare tumor and accounts for 5-10% of childhood tumors and, despite of the benign histological features, few studies on inflammatory cells and response in craniopharyngioma have been published.The aim of this word was to known about inflammation and immunoresponce in Craniopharyngiomas, which were evaluated thought immunohistochemistry. HIF1a, IFI16, TNF-α, TNF-λ, HMC-2, interleukins 6, CD4, CD20, CD68, CD57, Fascin, plasma cells were used. Tumors were divided between recurrence vs no recurrence and brain infiltration. Methods and materials:We retrospectively evaluated clinico-pathological findings in 56 patients with craniopharyngioma (CP). Based on histopathological and immunohistochemical findings and on clinical presentation, tumor size and follow-up data were correlated with emphasis in the inflammatory response.Results: 45 were adamantinomatous craniopharyngiomas and 11 were papillary craniopharyngiomas. Inflammation was higher in the adamantinomatous type than in the papillary type and was associated with gliosis, dystrophic calcification, and wet keratin formation, as well as tumour size and the duration of patients' follow-up. There was a statistically significant correlation between inflammation in craniopharyngioma and CD4 (p=0.041), CD20 (Phi=0.652, p=0.000), CD68 (Phi=0.493, p=0.000), NK (Phi=0.456, p=0.040) MHC-II (Phi=0.476, p=0.014), and IFI-16(Phi=0.436, p=0.031). However, there was no correlation between IL-6 immunoexpression and inflammation. Cases with more severe inflammation were associated with a shorter follow-up period than cases in which no inflammation was present (Log Rank text p=0.07, IC95%). Conclusions:These data suggest that macrophages and inflammatory response may act as activators in craniopharyngiomas. This may be involved in tumor cell proliferation and malignant transformation. Understanding the mechanism of these differences may be critical in the development of novel immunotherapies for CP, as a treatment strategy for CP and to illustrate possible physiological pathways responsible for the therapeutic benefit observed. Further studies are needed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Running Head: Craniopharyngioma and Immune Response

TS¹,

SL²,

HC³

2015

J Neurol Neurosci

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“…6 The cystic component of craniopharyngioma are possibly the result of an active production of the fluid by the epithelial cells of tumor. [14][15][16] This portion of the tumor is associated to a major risk of recurrence in spite of the presence of benign histological features, thus suggesting a proliferative mechanism in its formation and growth. Mechanical action of withdrawing the intratumoral liquid in every application could be one of the mechanisms of the decrease in tumor volume with IFNα treatment.…”

Section: Discussionmentioning

confidence: 99%

Cyst Wall Calcification Following Intracavitary Alpha Interferon Chemotheraphy for a Huge Cystic Craniopharyngioma in a Child: Case Report

Göksu¹,

Kazan²,

Eker³

et al. 2015

Turkiye Klinikleri J Case Rep

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C raniopharyngiomas are histologically benign and slow-growing lesions which originate from the embryonic remnants of squamous cells through the hypophyseal-pharyngeal duct. They are the most common non-glial tumors in childhood.1 In children, the adamantinomatous variant is prevalent and 90% of tumors have cystic characteristic. 2Due to the location of the tumor, with variable involvement of the pituitary stalk, gland, hypothalamus, optic nerves and chiasm, complete removal with preservation of all endocrine and visual function is achieved in a small number of cases.3,4 Furthermore, even after complete macroscopic resection, the recurrence rate ranges from 23 to 50%. A AB BS ST TR RA AC CT T Craniopharyngiomas are challenging lesions to resect completely and safely due to neighbouring on the critical neurovascular structures. Intracystic interferon alpha (IFNα) chemotheraphy had been used as an alternative treatment for predominantly cystic craniopharyngiomas in a limited number of patients. In this report, we presented a case of a huge cystic craniopharyngioma managed with the intracavitary IFNα application. Following the three treatment cycles, increased calcification on the solid portion of the tumor with the significantly reduction of tumor volume were observed. To our knowledge, such a this finding following the intracystic treatment with IFNα has not been reported in the literature. Further reported series and long-term follow-up could reveal whether this therapeutic option provides a definitive tumor control particularly in patients with developing calcification during the treatment.K Ke ey y W Wo or rd ds s: : Craniopharyngioma; interferon-alpha; magnetic resonance imaging Ö ÖZ ZE ET T Kraniofarinjiyomlar kritik nöral ve damarsal yapılarla yakın ilişkisi nedeniyle tam ve gü-venli rezeksiyonları güç lezyonlardır. Kist içi interferon alfa (IFNα) kemoterapisi, çoğunluğu kistik tümörlerde alternatif bir tedavi yöntemi olarak sınırlı bir hasta grubunda kullanılmıştır. Bu yazıda, kist içi IFNα ile tedavi edilen dev kistik kraniofarinjiyomalı bir olguyu sunduk. Üç tedavi döngüsü sonrası kist hacminde belirgin azalmayla birlikte tümörün solid bölümünde kalsifikasyon artışı gözlendi. Bilgilerimize göre, kist içi IFNα tedavisi sonrası böyle bir bulgu şimdiye dek literatürde bildirilmemiştir. Daha geniş seriler ve uzun takipler bu tedavi seçeneğinin, özellikle tedavi sırasında kalsifikasyon gelişen olgularda kalıcı bir tümör kontrolü sağlayıp, sağlamayacağını ortaya koyabilir.A An na ah ht ta ar r K Ke el li im me el le er r: : Kraniofarinjiyom; interferon-alfa; manyetik rezonans görüntüleme T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J C Ca as se e R Re ep p 2 20 01 15 5; ;2 23 3( (2 2)

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“…Indeed, the formation mechanism of cystic fluid has always been debated: it could be the result of blood-brain barrier impairment, 3 but surely an active secretory process takes part in its formation.…”

Section: Role Of Immune System Response: Defensinsmentioning

confidence: 99%

Molecular pathogenesis of craniopharyngioma: switching from a surgical approach to a biological one

Pettorini

Frassanito

Caldarelli

et al. 2010

FOC

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Craniopharyngioma has long been considered a benign tumor because of its pathological aspect. This primordial view of craniopharyngioma fit with the primitive treatment attempts based on blind resection of the tumor each time it recurred. The limits of this management strategy were proven early by the high morbidity related to the resection and recurrence risk despite radical lesion removal. Nowadays, craniopharyngioma must be considered a complex molecular disease, and a detailed explanation of the mechanisms underlying its aggressive biological and clinical behavior, despite some benign pathological features, would be the first step toward defining the best management of craniopharyngioma. Indeed, advances in the knowledge of the molecular mechanisms at the base of craniopharyngioma oncogenesis will lead to comprehension of the critical checkpoints involved in neoplastic transformation. The final research target will be the definition of new biological agents able to reverse the neoplastic process by acting on these critical checkpoints. This biological approach will lead to a refined therapy combining higher efficacy and safety with lower morbidity. In this paper the authors reveal state-of-the-art comprehension of the molecular biology of craniopharyngioma and the consequent therapeutic implications.

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Analysis of Fluid in Craniopharyngioma-Related Cysts in Children: Proteins, Lactate and pH

Cited by 20 publications

References 9 publications

Running Head: Craniopharyngioma and Immune Response

Running Head: Craniopharyngioma and Immune Response

Cyst Wall Calcification Following Intracavitary Alpha Interferon Chemotheraphy for a Huge Cystic Craniopharyngioma in a Child: Case Report

Molecular pathogenesis of craniopharyngioma: switching from a surgical approach to a biological one

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