Analysis of fortuitous matches in a STR genotype database from Mexico and its forensic efficiency parameters

Abstract

Background: Commercial kits for Human Identification (HID) purposes, based on 15 short tandem repeat (STR) regions, allow the resolution of most forensic and paternity cases. However, some pitfalls arise in situations such as identification of missing persons, disaster victims, and in motherless paternities. We describe nine fortuitous matches found during the inclusion of new DNA profiles and/or searching for missing persons within a Mexican STR database (N = 2000). For these cases, we estimated both the likelihood ratio (LR) and the modified LR according to National Research Council (NRC) recommendations (i.e., LR NRC ).

Identification of the Remains of an Adult Using DNA from Their Deciduous Teeth as a Reference Sample

“…The gain or loss of tandem repeats could lead to false maternal or paternal exclusions [30,32]. In addition, erroneous results can be produced by false matches with close family members or even with people who are completely unrelated to the victim, such that, in some cases, a probability of paternity greater than 99.99% does not necessarily indicate biological paternity [30,31,[38][39][40][41]. Poetsch et al [31] investigated how many wrong paternity inclusions could be detected when comparing [13][14][15] STRs between 336 children and 348 unrelated men.…”

“…However, they are expensive and time-consuming and are not available in most developing countries [47]. Even with these systems, the lack of informative reference samples (first-degree relatives) is the most common problem in identifying unknown corpses [41,48]. Thus, whenever possible, it is preferable to use reference samples from the putative victim as a source of DNA for identification.…”

A High-Performance Database Management System for Managing and Analyzing Large-Scale SNP Data in Plant Genotyping and Breeding Applications

“…DNA fingerprinting can be used for identification of plant individuals, which is also valuable for determining kinship in human and animal [3][4][5][6]. Currently, DNA fingerprinting technology is an effective tool used in plant sciences, human genetics, and animal breeding-related fields [7][8][9][10][11][12][13][14][15]. DNA fingerprints also play an extremely important role in plant breeding [16][17][18], which requires accurate plant genotyping to ensure consistency in the genetics and physiology of improved plant cultivars [19][20][21][22].…”