Analysis of Gender Difference of Cardiac Risk Biomarkers Using hGH-Transgenic Mice

Abstract

We investigated gender difference in the effects of chronic exposure to human growth hormone (hGH) on cardiac risk biomarkers using transgenic mice with non-pulsatile circulating hGH. Blood plasma was obtained from transgenic and control mice at 8, 12, and 16 weeks of age, and was used for the measurement of hGH and the following cardiac risk biomarkers: total cholesterol (CHO), triglyceride (TG), HDL cholesterol (HDL), LDL cholesterol (LDL), non esterified free fatty acids (NEFA), and lipid peroxides (LPO

Mice with gene alterations in the GH and IGF family

“…Phenotype Male transgenic mice from Gunzburg have higher plasma LDL-cholesterol and lipid peroxides and increased heart weights and lipid accumulation in liver compared to WT counterparts [142], suggesting a potential cardiac risk for male mice chronically exposed to hGH via the mammary gland. The body size of these mice does not differ from controls.…”