Analysis of Granulocyte Transfusions in Patients with Infections and Neutropenia: A Single Center Experience

Lee, Sena; Hu, Youmi; Eom, Hyeon Seok; Lee, Hyewon; Lee, Eun-Young; Kong, Sun-Young

doi:10.17945/kjbt.2016.27.3.247

Cited by 2 publications

(4 citation statements)

References 20 publications

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“…In this retrospective analysis performed on 54 patients with hematologic diseases, chemotherapy was the most common cause of neutropenia (42 people, 77.8%), followed by hematopoietic stem cell transplantation (7 people, 7.4%). This is similar to a previous study showing that chemotherapy is the most common cause of decreased neutrophil counts in the majority (73–80%) of cases [7].…”

Section: Discussionsupporting

confidence: 92%

“…This increment is lower than that reported in the previous studies which showed increase of approximately 0.6–2.6×10 9 /L of ANCs after an average GTx of 40–80×10 9 /L [68910]. A domestic study has also reported that with an average transfused granulocyte count of approximately 50×10 9 /L, neutrophil counts are increased to 1.0×10 9 /L in 84% of cases [7]. This percentage is higher than that (37%, 20/54) in the present study.…”

Section: Discussionmentioning

confidence: 62%

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Analysis of hematologic parameters of donors, patients, and granulocyte concentrates to predict successful granulocyte transfusion

et al. 2019

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Background Granulocyte transfusion (GTx) is performed as a supportive therapy in severe neutropenic patients caused by various conditions. The study aimed to analyze the hematologic parameters of donors, patients, and granulocyte concentrates to predict successful GTx. Methods This study was performed in 281 donors, with their granulocyte concentrates being collected through apheresis, and in 54 severe neutropenic patients who had various hematologic diseases. Complete blood cell counts of donors pre- and post-apheresis, granulocyte concentrates, and patients pre- and post-GTx were analyzed. Patients were divided into two groups according to survival at discharge (Group S, survival; Group D, dead) to compare various factors including age, infection status, pre- and post-GTx total white blood cell counts (TWBCC) and absolute neutrophil counts (ANC), total number of GTx, infused TWBCC and ANC per weight, and use of G-CSF during therapy. Results Overall data of patients showed that both TWBCC and ANC were significantly increased after GTx (median values at pre-GTx, TWBCC=0.40×10 9 /L, ANC=0.14×10 9 /L; post-GTx, TWBCC=0.57×10 9 /L, ANC=0.29×10 9 /L, both P <0.0001). After GTx, Group S (N=25) showed significantly higher TWBCC and ANC than Group D (N=29) ( P =0.01 and P =0.04, respectively). Using different cutoff levels, post-GTx TWBCC greater than 0.5×10 9 /L showed statistically significant difference between the two groups ( P <0.01). None of the other factors showed statistically significant differences. Conclusion The TWBCC and ANC after GTx were significant factors to predict patients' outcome. Therefore, follow-up of those two parameters may be helpful to select or consider other therapeutic modalities including additional GTx.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 62%

Analysis of hematologic parameters of donors, patients, and granulocyte concentrates to predict successful granulocyte transfusion

et al. 2019

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“…This increase is higher than reported in other studies, showing a 0.6-2.6 ×10³/µL neutrophil increase (10,11). In another study, 84% of patients reported an increase in the number of neutrophils to 1 ×10³/µL (6). The reason for the increase in neutrophil value at various levels in studies may be that patient groups' characteristics are different and affected by treatment methods other than GT.…”

Section: Discussionmentioning

confidence: 64%

“…Differences in infection severity or infection factor may have caused this condition in patients where the clinical response was not achieved, although there was a hematological response. In a retrospective study conducted in 2016, a total of 25 patients were given GT, and the hematological response was observed in 21 (84%) of the patients, and no hematological response was observed in 4 (16%) (6). After GT in studies, hematological response and recovery rate of clinical symptoms were observed as 68,2%, 50%, and 40% respectively (7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

The effect of granulocyte transfusion on engraftment in patients with allogeneic hematopoietic stem cell transplantation

İTMEÇ,

ÇELİK,

ÜNAL

2023

Journal of Health Sciences and Medicine

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Aim: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is still one of the most effective treatments for many hematological malignancies. However, especially infections and neutropenic fever increase mortality during the engraftment development process after allo-HSCT. This study investigated the effect and safety profile of granulocyte transfusion (GT) on engraftment in patients with neutropenic fever after allo-HSCT. Material and Method: We investigated 32 patients with hematological malignancies who had neutropenic fever following allo-HSCT between June 2018 and February 2020. Seventeen patients were given GT and defined as GT group (GTG). GT was given once daily until improvement in clinical and laboratory parameters (neutrophil >0.5 ×10³/µL, platelet >20 ×10³/µL). Fifteen patients who did not receive GT were included as a control group (CG). Results: By comparing leukocyte levels between the start and end of GT, the median leukocyte increase was shown as 1.93 (0.37- 10.21) ×10³/µL (p=0.001). Similarly, the median neutrophil increase was 1.14 (0.25-9.24) ×10³/µL (p=0.001). A total of 65 GTs were administered, the average number of days was 4±1. The average dose of infused granulocyte was 4 ×1010/unit. In GTG, neutrophil and platelet engraftments occurred on average at 14±2 and 10±2 days, respectively. In CG, neutrophil and platelet engraftments occurred on average 15±2 and 12±3 days, respectively. There was no statistically significant difference in neutrophil and platelet engraftment between the two groups (p=0.4, p=0.06, respectively). Conclusion: GT was observed to be effective in managing complications such as neutropenic fever and sepsis after allo-HSCT by shortening the duration of neutropenia and increasing neutrophil and leukocyte values. Although statistical significance was not observed in our study, it was observed that the engraftment times were shortened with GT.

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Analysis of Granulocyte Transfusions in Patients with Infections and Neutropenia: A Single Center Experience

Cited by 2 publications

References 20 publications

Analysis of hematologic parameters of donors, patients, and granulocyte concentrates to predict successful granulocyte transfusion

Analysis of hematologic parameters of donors, patients, and granulocyte concentrates to predict successful granulocyte transfusion

The effect of granulocyte transfusion on engraftment in patients with allogeneic hematopoietic stem cell transplantation

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