Analysis of Grey Matter in Thalamus and Basal Ganglia Based on EEG α3/α2 Frequency Ratio Reveals Specific Changes in Subjects with Mild Cognitive Impairment

Moretti, Davide; Paternicò, Donata; Binetti, Giuliano; Zanetti, Orazio; Frisoni, Giovanni B.

doi:10.1042/an20120058

Cited by 19 publications

(14 citation statements)

References 75 publications

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“…Complex patterns involving subcortical networks have been described by Moretti et al in the setting of memory impairment and dementias. 39 This type of quantitative analysis may provide a fundamentally different observation than the current qualitative assessment as presented here.…”

Section: Discussionmentioning

confidence: 84%

Discordant Observation of Brain Injury by MRI and Malignant Electroencephalography Patterns in Comatose Survivors of Cardiac Arrest following Therapeutic Hypothermia

Mettenburg¹,

Agarwal²,

Baldwin³

et al. 2016

AJNR Am J Neuroradiol

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Background and Purpose Malignant EEG patterns are considered predictive of poor outcome in comatose survivors of cardiac arrest. We hypothesize that malignant patterns by EEG are associated with evidence of more severe brain injury on MRI. Materials and Methods Retrospective review of clinical, imaging and EEG data of 33 adult comatose survivors of cardiac arrest following therapeutic hypothermia was performed. Outcomes measured included discharge destination and survival. Imaging studies were visually scored for severity of brain injury. Mean whole brain apparent diffusion coefficient (wbADC) and percentage of severely injured brain (ADC < 700 ×10−6mm2/sec) were calculated. Continuous EEG interpretation was characterized as malignant or non-malignant. Nonparametric tests were performed to assess the relationship of patient outcome, MRI and EEG patterns. Results Subjects with anatomic evidence of diffuse brain injury were less likely to have malignant EEG patterns. Subjects with malignant EEG patterns, invariably associated with bad outcomes, were observed to have wbADC measures similar to subjects with non-malignant EEG patterns and good outcome and different than subjects with non-malignant EEG patterns and bad outcomes. Regional hippocampal or basal ganglia injury was associated with bad outcome regardless of EEG findings. Conclusions We found discordant evidence of brain injury by MRI and EEG, refuting our initial hypothesis. Malignant EEG patterns were generally more frequent in subjects with less severe brain injury by MRI. These findings suggest a complementary role of MRI and EEG and support the aggressive treatment of malignant EEG patterns in this population.

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Section: Discussionmentioning

confidence: 84%

Discordant Observation of Brain Injury by MRI and Malignant Electroencephalography Patterns in Comatose Survivors of Cardiac Arrest following Therapeutic Hypothermia

Mettenburg¹,

Agarwal²,

Baldwin³

et al. 2016

AJNR Am J Neuroradiol

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“…Interconnected with prefrontal cortical structures, the caudate nucleus has been implicated in a wide range of cognitive functions (Haber, 2016; Zhang, et al, 2012). Studies have also reported volumetric changes of the caudate in neurological and psychiatric conditions, including mild cognitive impairment (Moretti, et al, 2012) and Alzheimer’s disease (Jiji, et al, 2013; Yang, et al, 2012), but the literature of healthy aging is limited. An earlier study reported volumetric reduction of the right caudate in relation to association memory deficits in older healthy adults (Bauer, et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Interconnected with prefrontal cortical structures, the caudate nucleus has been implicated in a wide range of cognitive functions (Haber, 2016;Zhang, Ide, & Li, 2012). Studies have also reported volumetric changes of the caudate in neurological and psychiatric conditions, including mild cognitive impairment (Moretti, Paternico, Binetti, Zanetti, & Frisoni, 2012) and…”

Section: Gray Matter Volumetric Reduction In Association With Agingmentioning

confidence: 99%

Structural and functional cerebral bases of diminished inhibitory control during healthy aging

Ide

Chao

et al. 2018

Human Brain Mapping

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Inhibitory control or the ability to refrain from incorrect responses is a critical executive function known to diminish during aging. Imaging studies have elucidated cerebral changes that may underlie the age-related deficits. However, it remains unclear whether the structural and functional changes occur in the same brain regions and whether reduced gray matter volumes (GMV) mediate decreased activation during inhibition. Here, in a sample of 149 participants, we addressed the issues using structural and functional magnetic resonance imaging. Individual's response inhibition was evaluated by the stop signal reaction time (SSRT) in a stop signal task. The results showed that age was associated with prolonged SSRT across participants. Many cortical and subcortical regions demonstrated age-related reduction in GMV and activation to response inhibition. Additionally, age-related diminution in inhibitory control, as indexed by the SSRT, was associated with both shared and distinct morphometric and functional changes. Voxel-based morphometry demonstrated age-related reduction in GMV in the right dorsolateral prefrontal cortex and caudate head as well as bilateral insula, in association with prolonged SSRT. In a contrast of stop success versus go success trials, age was associated with lower activation in the medial and inferior frontal cortex and inferior parietal cortex. Further, reduction in GMV mediated age-related differences in activations only of the medial prefrontal cortex, providing limited evidence for structure function association. Thus, the decline in inhibitory control, as evidenced in the stop signal task, manifest with both shared and distinct structural and functional processes during aging.

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“…The fimbria was included in the hippocampal body, while the grey matter rostral to the fimbria was excluded. The hippocampal tail was traced until it was visible as an oval shape located caudally and medially to the trigone of the lateral ventricles [54] [55]. The intraclass correlation coefficients were 0.95 for the hippocampus and 0.83 for the amygdala.…”

Section: Mri Scans and Amygdalo-hippocampal Atrophy Evaluationmentioning

confidence: 99%

The Contribution of EEG to the Diagnosis of Dementia

Moretti¹

2014

JBiSE

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Changes induced by cerebrovascular damage (CVD) and amigdalo-hippocampal atrophy (AHC) on brain rhythmicity as revelaled by scalp electroencephalography (EEG) were evaluated in a cohort of subjects with mild cognitive impairment (MCI) in order to detect different EEG patterns due to the vascular or degenerative impairment. All subjects underwent EEG recording and magnetic resonance imaging (MRI). EEGs were recorded at rest. Relative power was separately computed for delta, theta, alpha1, alpha2, and alpha 3 frequency bands. Increased delta power and decreased alpha2 power were associated with the load of cerebrovascular damage (CVD). Moreover, the theta/alpha 1 ratio could be a reliable index for the estimation of the individual extent of CV damage. No association of vascular damage was observed with alpha3 power. On the other side, moderate hippocampal atrophy was related to an increase of alpha2 and alpha3 frequency power ratio. Our results show that different EEG markers are associated to vascular dementia and Alzheimer's disease (AD). EEG markers could be expression of different global network pathological changes, helping in differentiation of prodromal AD from vascular demented patients. MCI stated that EEG markers could have a prospective value in differential diagnosis between vascular and degenerative MCI. Keywords EEG, Dementia, Brain Rhythms Shared Procedures EEG RecordingsAll recordings were obtained in the morning with subjects resting comfortably. Vigilance was continuously monitored in order to avoid drowsiness.The EEG activity was recorded continuously from 19 sites by using electrodes set in an elastic cap (Electro-Cap International, Inc.) and positioned according to the 10 -20 International system (Fp1, Fp2, F7, F3, Fz, F4, F8, T3, C3, Cz, C4, T4, T5, P3, Pz, P4, T6, O1, O2). The ground electrode was placed in front of Fz. The left and right mastoids served as reference for all electrodes. The recordings were used off-line to re-reference the scalp recordings to the common average. Data were recorded with a band-pass filter of 0.3 -70 Hz, and digitized at a sampling rate of 250 Hz (BrainAmp, BrainProducts, Germany). Electrodes-skin impedance was set below 5 kW. Horizontal and vertical eye movements were detected by recording the electrooculogram (EOG). The recording lasted 5 minutes, with subjects with closed eyes. Longer recordings would have reduced the variability of the data, but they would also have increased the possibility of slowing of EEG oscillations due to reduced vigilance and arousal. EEG data were then analyzed and fragmented off-line in consecutive epochs of 2 seconds, with a frequency resolution of 0.5 Hz. The average number of epochs analyzed was 140 ranging from 130 to 150. The EEG epochs with ocular, muscular and other types of artifacts were discarded.

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Analysis of Grey Matter in Thalamus and Basal Ganglia Based on EEG α3/α2 Frequency Ratio Reveals Specific Changes in Subjects with Mild Cognitive Impairment

Cited by 19 publications

References 75 publications

Discordant Observation of Brain Injury by MRI and Malignant Electroencephalography Patterns in Comatose Survivors of Cardiac Arrest following Therapeutic Hypothermia

Discordant Observation of Brain Injury by MRI and Malignant Electroencephalography Patterns in Comatose Survivors of Cardiac Arrest following Therapeutic Hypothermia

Structural and functional cerebral bases of diminished inhibitory control during healthy aging

The Contribution of EEG to the Diagnosis of Dementia

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