This study develops empirical fragility curves for concrete and masonry buildings in Haiti, utilizing data from the 2021 earthquake. A dataset of 3527 buildings from the StEER database, encompassing a diverse range of building types, is used. These buildings types include reinforced concrete structures with masonry infills, confined masonry buildings, reinforced masonry bearing walls, and unreinforced masonry bearing walls. Shakemaps from the USGS are utilized to assess the earthquake’s intensity at each building, with the peak ground acceleration (PGA) as the intensity measure. Damage is classified into five distinct states: no damage, minor, moderate, severe, and partial or total collapse. For each of these states, the corresponding probabilities of exceedance are calculated, and log-normal cumulative distribution functions were fitted to those data to produce empirical fragility curves. The results show a notable similarity in performance among the four types, each having high probability of failure even under low-intensity earthquakes. Total fragility curves (including all four building types) are developed subsequently and they are convolved to the probabilistic seismic hazard map of Haiti to assess the seismic risk. This includes estimating the annual probability of partial/total collapse and the probability of partial/total collapse in the event of 475-year and 2475-year earthquakes. The results indicate a significant risk, with up to 64% probability of collapse in certain areas for the 2475-year earthquake and a probability of collapse of 15% for a 475-year earthquake. These findings underscore the critical vulnerability of Haiti’s buildings to seismic events and the urgent need for their retrofit.